التفاصيل البيبلوغرافية
| العنوان: |
Advanced donor age does not increase risk of hepatocellular carcinoma recurrence after liver transplantation: a retrospective two‐centre analysis using competing risk analysis. |
| المؤلفون: |
Cusumano, Caterina, De Carlis, Luciano, Centonze, Leonardo, Lesourd, Romain, Levi Sandri, Giovanni Battista, Lauterio, Andrea, De Carlis, Riccardo, Ferla, Fabio, Di Sandro, Stefano, Camus, Christophe, Jézéquel, Caroline, Bardou‐Jacquet, Edouard, Rayar, Michel |
| المصدر: |
Transplant International; Oct2021, Vol. 34 Issue 10, p1948-1958, 11p |
| مصطلحات موضوعية: |
HEPATOCELLULAR carcinoma, LIVER transplantation, RISK assessment, COMPETING risks, PROPENSITY score matching, RETROSPECTIVE studies |
| مستخلص: |
Summary: The impact of donor age on the recurrence of hepatocellular carcinoma (HCC) after liver transplantation is still debated. Between 2002 and 2014, all patients transplanted for HCC in 2 European liver transplantation tertiary centres were retrospectively reviewed. Risk factors for HCC recurrence were assessed using competing risk analysis, and the impact of donor age < or ≥65 years and < or ≥80 years was specifically evaluated after propensity score matching. 728 patients transplanted with a median follow‐up of 86 months were analysed. The 1‐, 3‐ and 5‐year recurrence rates were 4.9%, 10.7% and 13.9%, respectively. In multivariable analysis, recipient age (sHR: 0.96 [0.93; 0.98], P < 0.01), number of lesions (sHR: 1.05 [1.04; 1.06], P < 0.001), maximum size of the lesions (sHR: 1.37 [1.27; 1.48], P < 0.01), presence of a hepatocholangiocarcinoma (sHR: 6.47 [2.91; 14.38], P < 0.01) and microvascular invasion (sHR: 3.48 [2.42; 5.02], P < 0.01) were significantly associated with HCC recurrence. After propensity score matching, neither donor age ≥65 (P = 0.29) nor donor age ≥80 (P = 0.84) years increased the risk of HCC recurrence. In conclusion, donor age was not found to be a risk factor for HCC recurrence. Patients listed for HCC can receive a graft from an elderly donor without compromising the outcome. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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