التفاصيل البيبلوغرافية
| العنوان: |
Effects of pancreas–kidney transplantation on diabetic retinopathy. |
| المؤلفون: |
Giannarelli, Rosa, Coppelli, Alberto, Sartini, Mariasole, Aragona, Michele, Boggi, Ugo, Vistoli, Fabio, Rizzo, Gaetano, Prato, Stefano Del, Mosca, Franco, Marchetti, Piero |
| المصدر: |
Transplant International; May2005, Vol. 18 Issue 5, p619-622, 4p |
| مصطلحات موضوعية: |
DIABETES complications, KIDNEY transplantation, DIABETIC retinopathy, RETINAL diseases, BODY weight, TRANSPLANTATION of organs, tissues, etc. |
| مستخلص: |
The effects of pancreas transplantation (PTx) on diabetic retinopathy (DR) are still debated. We studied the course of DR in 48 patients (age: 40 ± 7 years; males/females 26/22, body mass index (BMI): 23.0 ± 2.4 kg/m2, duration of diabetes: 24 ± 8 years) bearing a successful PTx (combined with a kidney). Follow-up ranged 6–60 months (median: 17 months). Before transplantation, according to the Eurodiab Study classification, 12 patients (25%) had nonproliferative retinopathy (NPDR; mild, moderate or severe), and 36 patients (75%) had laser-treated and/or proliferative retinopathy (LT/PDR). During the follow-up, in the NPDR group improvement/deterioration was defined as regression/progression to a lower/higher retinopathy grade; in the LT/PTD group, stabilization was defined as no new neo-vessel formation or development of new lesions requiring laser-treatment. In the NPDR group, five (41.7%) patients improved of one or more lesion grading, three (25%) patients showed no change, and four (33.3%) patients progressed of one grade. In the LT/PDR group, the post-transplant data were: stabilization in 35 (97%) patients, and worsening in one (3%) patient. The number of improved/stabilized patients was significantly higher in the transplanted than in a control group of nontransplanted type 1 diabetic patients. In conclusion, despite a relatively short follow-up period, successful PTx in our cohort of patients was associated with improvement and/or stabilization of DR in the majority of recipients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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