التفاصيل البيبلوغرافية
| العنوان: |
HOPE Mitigates Ischemia-Reperfusion Injury in Ex-Situ Split Grafts: A Comparative Study With Living Donation in Pediatric Liver Transplantation. |
| المؤلفون: |
Rossignol, Guillaume1,2,3,4 guillaume.rossignol@chu-lyon.fr, Muller, Xavier1,2,3, Ruiz, Mathias5, Collardeau-Frachon, Sophie6, Boulanger, Natacha1, Depaulis, Celia7, Antonini, Teresa8, Dubois, Remi4, Mohkam, Kayvan1,2,4, Mabrut, Jean-Yves1,2,3 |
| المصدر: |
Transplant International. 2024, p1-8. 8p. |
| مصطلحات موضوعية: |
*LIVER transplantation, *REPERFUSION injury, *SURGICAL complications, *SYSTOLIC blood pressure, *COLD storage |
| مستخلص: |
Optimizing graft preservation is key for ex-situ split grafts in pediatric liver transplantation (PSLT). Hypothermic Oxygenated Perfusion (HOPE) improves ischemia-reperfusion injury (IRI) and post-operative outcomes in adult LT. This study compares the use of HOPE in exsitu partial grafts to static cold storage ex-situ partial grafts (SCS-Split) and to the gold standard living donor liver transplantation (LDLT). All consecutive HOPE-Split, SCS-Split and LDLT performed between 2018–2023 for pediatric recipients were included. Postreperfusion syndrome (PRS, drop ≥30% in systolic arterial pressure) and reperfusion biopsies served as early indicators of IRI. We included 47 pediatric recipients (15 HOPESplit, 17 SCS-Split, and 15 LDLT). In comparison to SCS-Split, HOPE-Split had a significantly shorter cold ischemia time (CIT) (470min vs. 538 min; p =0.02), lower PRS rates (13.3% vs. 47.1%; p = 0.04) and a lower IRI score (3 vs. 4; p = 0.03). The overall IRI score (3 vs. 3; p = 0.28) and PRS (13.3% vs. 13.3%; p = 1) after HOPE-Split were comparable to LDLT, despite a longer CIT (470 min vs. 117 min; p < 0.001). Surgical complications, one-year graft, and recipient survival did not differ among the groups. In conclusion, HOPE-Split mitigates early IRI in pediatric recipients in comparison to SCSSplit, approaching the gold standard of LDLT. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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