Acute Rabbit Eye Model for Testing Subretinal Prostheses
| العنوان: | Acute Rabbit Eye Model for Testing Subretinal Prostheses |
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| المؤلفون: | Scott Thorogood, Tiezhu Lin, Stephanie Landeros, William R. Freeman, Fangting Li, Brandon Bosse, Dirk-Uwe Bartsch, Kristyn Huffman, Ying Xiao, Yuqin Wang, Yi Jing, Lingyun Cheng |
| المصدر: | Translational vision science & technology, vol 8, iss 5 Translational Vision Science & Technology |
| بيانات النشر: | Association for Research in Vision and Ophthalmology (ARVO), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, rabbit eye model, medicine.medical_specialty, acute visual electrophysiology eye model, genetic structures, medicine.medical_treatment, retinal prosthesis, Biomedical Engineering, Bioengineering, Neurodegenerative, Fundus (eye), Eye, Prosthesis, longitudinal OCT, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Opthalmology and Optometry, Ophthalmology, Retinitis pigmentosa, medicine, subretinal implantation, Eye Disease and Disorders of Vision, Assistive Technology, Retina, medicine.diagnostic_test, business.industry, Rehabilitation, Neurosciences, Retinal, Articles, Macular degeneration, medicine.disease, eye diseases, 3. Good health, Apposition, 030104 developmental biology, medicine.anatomical_structure, chemistry, Angiography, 030221 ophthalmology & optometry, sense organs, business |
| الوصف: | Author(s): Xiao, Ying; Wang, Yuqin; Li, Fangting; Lin, Tiezhu; Huffman, Kristyn; Landeros, Stephanie; Bosse, Brandon; Jing, Yi; Bartsch, Dirk-Uwe; Thorogood, Scott; Freeman, William R; Cheng, Lingyun | Abstract: PurposeSubretinal prostheses are a novel technology for restoring useful vision in patients with retinitis pigmentosa or age-related macular degeneration. We characterize the surgical implantation technique and functional time window of an acute rabbit eye model for testing of human subretinal prostheses.MethodsRetinal prostheses were implanted subretinally in 26 rabbits using a two-step technique. Fundus imaging, fluorescein fundus angiography, and optical coherence topography (OCT) were conducted postoperatively from days 1 to 21 to monitor prosthesis positioning and retinal anatomic changes.ResultsSuccessful implantation and excellent retina apposition were achieved in 84.6% of the rabbits. OCTs showed the overlying retina at full thickness for the first 2 days after implantation. Histology confirmed intact inner layers of the overlying retina until day 3. Progressive atrophy of the overlying retina was revealed by repeated OCTs; approximately 40% of the retina thickness remained on postoperative days 5 and 6.ConclusionsThe two-step implantation technique works well for the rabbit eye model with human prostheses. Rabbit retina may be used for acute electrophysiologic testing of a retinal prosthesis, but is unsuitable for chronic studies due to the merangiotic retina and its limited time window of validity.Translational relevanceThe improved efficacy in prosthesis surgery using this technique will circumvent the challenges in animal models that provide human-like features critical for the transition into human clinical trials. |
| وصف الملف: | application/pdf |
| تدمد: | 2164-2591 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8aa33b007c9463bc96e18060446d9bTest https://doi.org/10.1167/tvst.8.5.20Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bc8aa33b007c9463bc96e18060446d9b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21642591 |
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