Characterization of gut microbiome in mice model of depression with divergent response to escitalopram treatment
| العنوان: | Characterization of gut microbiome in mice model of depression with divergent response to escitalopram treatment |
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| المؤلفون: | Xi Hu, Hanping Zhang, Liang Fang, Peng Xie, Yifan Li, Jinlin Song, Xunmin Tan, Jiajia Duan, Jing Wu, Ping Ji, Yu Huang, Tingjia Chai, Peng Zheng, Libo Zhao, Deyu Yang |
| المصدر: | Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021) Translational Psychiatry |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Neurosciences. Biological psychiatry. Neuropsychiatry, Citalopram, Biology, Prevotellaceae, Pharmacology, Molecular neuroscience, Article, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Metabolomics, medicine, Animals, Humans, Escitalopram, Biological Psychiatry, Depression (differential diagnoses), Depression, Metabolism, Ribosomal RNA, biology.organism_classification, Antidepressive Agents, Gastrointestinal Microbiome, Psychiatry and Mental health, 030104 developmental biology, 030217 neurology & neurosurgery, Function (biology), RC321-571, Ruminococcaceae, medicine.drug |
| الوصف: | Depression is a common and heterogeneous mental disorder. Although several antidepressants are available to treat the patients with depression, the factors which could affect and predict the treatment response remain unclear. Here, we characterize the longitudinal changes of microbial composition and function during escitalopram treatment in chronic unpredictable mild stress (CUMS) mice model of depression based on 16 S rRNA sequencing and metabolomics. Consequently, we found that escitalopram (ESC) administration serves to increase the alpha-diversity of the gut microbiome in ESC treatment group. The microbial signatures between responder (R) and non-responder (NR) groups were significantly different. The R group was mainly characterized by increased relative abundances of genus Prevotellaceae_UCG-003, and depleted families Ruminococcaceae and Lactobacillaceae relative to NR group. Moreover, we identified 15 serum metabolites responsible for discriminating R and NR group. Those differential metabolites were mainly involved in phospholipid metabolism. Significantly, the bacterial OTUs belonging to family Lachnospiraceae, Helicobacteraceae, and Muribaculaceae formed strong co-occurring relationships with serum metabolites, indicating alternations of gut microbiome and metabolites as potential mediators in efficiency of ESC treatment. Together, our study demonstrated that the alterations of microbial compositions and metabolic functions might be relevant to the different response to ESC, which shed new light in uncovering the mechanisms of differences in efficacy of antidepressants. |
| تدمد: | 2158-3188 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2960bb659b2036520e5b8588edfc72afTest https://doi.org/10.1038/s41398-021-01428-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2960bb659b2036520e5b8588edfc72af |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21583188 |
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