Effects of NRG1 and DAOA genetic variation on transition to psychosis in individuals at ultra-high risk for psychosis
| العنوان: | Effects of NRG1 and DAOA genetic variation on transition to psychosis in individuals at ultra-high risk for psychosis |
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| المؤلفون: | Chad A. Bousman, Stephen J. Wood, Dennis Velakoulis, Christos Pantelis, Ashleigh Lin, Justine A. Ellis, Patrick D. McGorry, Raul A Chavez, Alison R. Yung, G.P. Amminger, Barnaby Nelson, Debra L. Foley, Ian P. Everall |
| المصدر: | Translational Psychiatry |
| بيانات النشر: | Nature Publishing Group, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Oncology, Adult, Male, medicine.medical_specialty, Psychosis, Heterozygote, Adolescent, Genotype, Neuregulin-1, Polymorphism, Single Nucleotide, Prodrome, 03 medical and health sciences, Cellular and Molecular Neuroscience, Young Adult, 0302 clinical medicine, Risk Factors, Internal medicine, Genetic variation, medicine, Humans, Genetic Predisposition to Disease, Bipolar disorder, Prospective Studies, Allele, Psychiatry, Prospective cohort study, gene, Biological Psychiatry, risk, Proportional Hazards Models, Psychiatric Status Rating Scales, neuregulin 1, Haplotype, digestive, oral, and skin physiology, Intracellular Signaling Peptides and Proteins, prediction, medicine.disease, prodrome, 030227 psychiatry, schizophrenia, Psychiatry and Mental health, Haplotypes, Psychotic Disorders, Original Article, Female, Psychology, Carrier Proteins, 030217 neurology & neurosurgery |
| الوصف: | Prospective studies have suggested genetic variation in the neuregulin 1 (NRG1) and 𝒟-amino-acid oxidase activator (DAOA) genes may assist in differentiating high-risk individuals who will or will not transition to psychosis. In a prospective cohort (follow-up=2.4–14.9 years) of 225 individuals at ultra-high risk (UHR) for psychosis, we assessed haplotype-tagging single-nucleotide polymorphisms (htSNPs) spanning NRG1 and DAOA for their association with transition to psychosis, using Cox regression analysis. Two NRG1 htSNPs (rs12155594 and rs4281084) predicted transition to psychosis. Carriers of the rs12155594 T/T or T/C genotype had a 2.34 (95% confidence interval (CI)=1.37–4.00) times greater risk of transition compared with C/C carriers. For every rs4281084 A-allele the risk of transition increased by 1.55 (95% CI=1.05–2.27). For every additional rs4281084-A and/or rs12155594-T allele carried the risk increased ∼1.5-fold, with 71.4% of those carrying a combination of ⩾3 of these alleles transitioning to psychosis. None of the assessed DAOA htSNPs were associated with transition. Our findings suggest NRG1 genetic variation may improve our ability to identify UHR individuals at risk for transition to psychosis. |
| اللغة: | English |
| تدمد: | 2158-3188 1215-5594 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a9014bd5df7f160feed436d5475c9aTest http://europepmc.org/articles/PMC3641410Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....49a9014bd5df7f160feed436d5475c9a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21583188 12155594 |
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