دورية
CBLC promotes the development of colorectal cancer by promoting ABI1 degradation to activate the ERK signaling pathway
| العنوان: | CBLC promotes the development of colorectal cancer by promoting ABI1 degradation to activate the ERK signaling pathway |
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| المؤلفون: | Li, Zhan, Yan, Guanyu, Yang, Meiqi, Liu, Xingwu, Lian, Yuan, Sun, Mingjun, Pan, Wenjun |
| المصدر: | Translational Oncology; July 2024, Vol. 45 Issue: 1 |
| مستخلص: | •CBLC levels was elevated in tumor tissues of CRC patients.•CBLC promoted CRC cell proliferation, migration and invasion.•CBLC accelerated tumor growth and promoted tumor metastasis to the lung.•CBLC induced the activation of ERK signaling pathway.•CBLC decreased ABI1 protein levels through its ubiquitin ligase activity.•ABI1 overexpression abolished the effects of CBLC on the tumorigenesis of CRC. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 19447124 19365233 |
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| DOI: | 10.1016/j.tranon.2024.101992 |