دورية
Frequency and Clinicopathological Profile Associated with Braf Mutations in Patients with Advanced Melanoma in Spain
| العنوان: | Frequency and Clinicopathological Profile Associated with Braf Mutations in Patients with Advanced Melanoma in Spain |
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| المؤلفون: | Lopez-Martin, Jose A., Arance Fernández, Ana, Ríos-Martín, Juan José, Hernández-Losa, Javier, Alós Hernández, Lucía, Cerezuela Fuentes, Pablo, Ortiz Reina, Sebastián, Ortega Izquierdo, Eugenia, Martí, Rosa M, Soberino García, Jesús, Ferrer Fábrega, Berta, Rodríguez Peralto, José Luis |
| المصدر: | Translational Oncology; June 2020, Vol. 13 Issue: 6 |
| مستخلص: | Real-world data on BRAFmutation frequency in advanced melanoma are lacking in Spain. Moreover, data available on clinicopathological profile of patients with advanced BRAF-mutant melanoma are currently limited. This study aimed to assess the frequency of BRAFV600 mutations in Spanish patients with advanced or metastatic melanoma and to identify clinical and histopathological features associated with BRAF-mutated tumors. A multicenter, cross-sectional epidemiological study was conducted in 33 Spanish hospitals in adult patients with stage IIIc/IV melanoma. A total of 264 patients were included. The median age was 68 years and 57% were male. Melanoma mainly involved skin with intermittent (40.4%) and low or no sun exposure (43.5%). Most patients (85.6%) had stage IV disease (M1a: 19.3%; M1b: 13.3%; M1c: 22.7%). Serum lactate dehydrogenase levels were elevated in 20% of patients.Superficial spreading melanoma was the most frequent histological type (29.9%). Samples were predominantly obtained from metastases (62.7%), mostly from skin and soft tissues (80%). BRAFmutation analysis was primarily performed using the Cobas 4800 BRAFV600 Mutation Test (92.8%) on formalin-fixed, paraffin-embedded tissue (95.8%). BRAFmutations were detected in 41.3% of samples. Multivariate analysis identified age (odd ratio [OR] 0.975) and stage IV M1a (OR 2.716) as independent factors associated with BRAFmutation. The frequency of BRAFmutations in tumor samples from patients with advanced or metastatic melanoma in Spain was 41.3%. BRAFmutations seem to be more frequent in younger patients and stage M1a patients. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 19447124 19365233 |
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| DOI: | 10.1016/j.tranon.2020.100750 |