التفاصيل البيبلوغرافية
| العنوان: |
Targetable Gene Fusions Associate With the IDH Wild-Type Astrocytic Lineage in Adult Gliomas |
| المؤلفون: |
Ferguson, Sherise D, Zhou, Shouhao, Huse, Jason T, de Groot, John F, Xiu, Joanne, Subramaniam, Deepa S, Mehta, Shwetal, Gatalica, Zoran, Swensen, Jeffrey, Sanai, Nader, Spetzler, David, Heimberger, Amy B |
| المصدر: |
Translational Neuroscience |
| بيانات النشر: |
Barrow - St. Joseph's Scholarly Commons |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
Adult, Astrocytes (pathology), Astrocytoma (genetics, pathology), Brain Neoplasms (genetics, Cell Lineage, Child, Female, Gene Fusion (genetics), Glioblastoma (genetics, Glioma (genetics, Humans, Isocitrate Dehydrogenase (genetics), Male, Mutation, Oligodendroglioma (genetics |
| الوصف: |
Gene fusions involving oncogenes have been reported in gliomas and may serve as novel therapeutic targets. Using RNA-sequencing, we interrogated a large cohort of gliomas to assess for the incidence of targetable genetic fusions. Gliomas (n = 390) were profiled using the ArcherDx FusionPlex Assay. Fifty-two gene targets were analyzed and fusions with preserved kinase domains were investigated. Overall, 36 gliomas (9%) harbored a total of 37 potentially targetable fusions, the majority of which were found in astrocytomas (n = 34). Within this lineage 11% (25/235) of glioblastomas, 12% (5/42) of anaplastic astrocytomas, 8% (2/25) of grade II astrocytomas, and 33% (2/6) of pilocytic astrocytoma harbored targetable fusions. Fusions were significantly more frequent in IDH wild-type tumors (12%, n = 31/261) relative to IDH mutants (4%; n = 4/109) (p = 0.011). No fusions were seen in oligodendrogliomas. The most frequently observed therapeutically targetable fusions were in FGFR (n = 12), MET (n = 11), and NTRK (n = 8). Several additional novel fusions that have not been previously described in gliomas were identified including EGFR:VWC2 and FGFR3:NBR1. In summary, targetable gene fusions are enriched in IDH wild-type high-grade astrocytic tumors, which will influence enrollment in and interpretation of clinical trials of glioma patients. |
| نوع الوثيقة: |
text |
| اللغة: |
unknown |
| العلاقة: |
https://scholar.barrowneuro.org/neurobiology/1607Test |
| الإتاحة: |
https://scholar.barrowneuro.org/neurobiology/1607Test |
| رقم الانضمام: |
edsbas.6E567FC8 |
| قاعدة البيانات: |
BASE |
