المؤلفون: Fernández-Zarzoso, Miguel¹ (AUTHOR), Gómez-Seguí, Inés² (AUTHOR), de la Rubia, Javier^1,3 (AUTHOR) delarubia_jav@gva.es

المصدر: Transfusion & Apheresis Science. Jun2019, Vol. 58 Issue 3, p247-253. 7p.

مصطلحات موضوعية: *CLINICAL indications, *BLOOD products, *CELL anatomy, *EXCHANGE, *THERAPEUTICS

مستخلص: Therapeutic plasma exchange (TPE) is the extracorporeal technique performed in an apheresis device were patient's plasma is separated from whole blood and removed, while the cellular blood components are returned to the patient together with a replacement fluid. By the extracorporeal removal of pathological substances and the replacement of deficient plasma components, it constitutes an important tool for the management of several disorders and it is a well-known and established treatment for numerous diseases. Additionally, overall available data confirm the safety and efficacy of TPE. Nevertheless, the quality of the evidence supporting the utility and efficacy of the procedure is diverse. This review attempts to compile the current indications of TPE in different disorders according to an extensive and updated literature review, with special focus on its present role and its validity in the twenty-first century medicine. [ABSTRACT FROM AUTHOR]

المؤلفون: Solves, Pilar¹ (AUTHOR) solves_pil@gva.es, Tur, Susana¹ (AUTHOR), Gómez-Seguí, Inés¹ (AUTHOR), Viel, María¹ (AUTHOR), Eiris, Juan¹ (AUTHOR), Planells, Yolanda¹ (AUTHOR), Rodríguez, Raquel¹ (AUTHOR), Peñalver, Isabel¹ (AUTHOR), Castro, Emma¹ (AUTHOR), de la Rubia, Javier¹ (AUTHOR)

المصدر: Transfusion & Apheresis Science. Jun2022, Vol. 61 Issue 3, pN.PAG-N.PAG. 1p.

مصطلحات موضوعية: *BLOOD transfusion reaction, *ERYTHROBLASTOSIS fetalis, *TERTIARY care, *ERYTHROCYTES, *MEDICAL screening, *HOSPITAL patients

مستخلص: Wra is the most common LIA in white population. The incidence of Wra antigen in Spanish population has been estimated to be 1 in 785 in blood donors, while anti-Wra was found in 2.7 % and 3.6 % of healthy donors and transfused patients respectively. Severe, even fatal hemolytic transfusion reactions and hemolytic disease of the newborn caused by anti-Wra have been reported. Since the reagent red blood cells used for antibody screening usually lack Wra antigen, the anti-Wra is not detected and hemolytic reaction could occur if transfusion is performed by type and screen approach. We report an acute hemolytic reaction due to anti-Wra in a patient with negative antibody screening. We have also reviewed the records of the hospital hemovigilance database in order to collect the previous hemolytic cases due to anti-Wra. During a 21-year period 461,539 red blood cell units have been transfused to 81,614 patients in our hospital. Alloimmnunization was detected in 3840 patients (0.83 %) and anti-Wra was detected in 22 patients (1/3709), 10 of whom had other alloantibodies, and only in 1 occasion (this case) has been implicated in mild hemolytic acute transfusion reaction. In our experience, the risk of fatal hemolytic reaction due to LIA in hospitals with blood services using the type and screen policy is extremely low. [ABSTRACT FROM AUTHOR]