التفاصيل البيبلوغرافية
| العنوان: |
Prospective evaluation of a transfusion policy of D+ red blood cells into D− patients. |
| المؤلفون: |
Gonzalez-Porras, Jose R., Graciani, Ignacio F., Perez-Simon, Jose A., Martin-Sanchez, Jesus, Encinas, Cristina, Conde, Maria P., Nieto, Maria J., Corral, Mercedes |
| المصدر: |
Transfusion; Jul2008, Vol. 48 Issue 7, p1318-1324, 7p, 4 Charts |
| مصطلحات موضوعية: |
ERYTHROCYTES, BLOOD cells, BLOOD donors, IMMUNIZATION, BLOOD transfusion |
| مستخلص: |
BACKGROUND: Although D− patients should receive red blood cells (RBCs) from D− donors, the scarcity of D− blood components in certain situations makes the transfusion of D+ RBCs unavoidable. Therefore it is recommended that guidelines be developed in order to standardize transfusion policy in these scenarios. STUDY DESIGN AND METHODS: We have prospectively evaluated a policy for the use of D+ RBCs in 905 D− patients. The amount of D− RBCs saved as well as the incidence of hemolytic reactions and anti-D alloimmunization were assessed. RESULTS: 554 patients received D− RBCs while 351 received a total of 1032 D+ RBCs, all of them within our criteria for the acceptable use of D+ RBCs. This strategy allowed us to save 25.6 percent of D− RBCs (1032 out of 4024 RBCs requested). No hemolytic reactions were reported. The incidence of alloimmunization was 21.4 percent. Most patients who developed anti-D did so within the first 2 or 4 RBCs transfused (64% after the first 2 RBCs transfused and 88% after the first 4). In multivariate analysis the age of less than 77 years was the only predictor for alloimmuization (HR = 2.48 [95% CI = 1.21-3.81]; p = 0.014). CONCLUSION: The use of D+ RBCs in selected D− patients does not induce adverse reactions and allows the saving of a significant number of D− RBCs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
