Type of plasma preparation used for plasma exchange and clinical outcome of adult patients with acquired idiopathic thrombotic thrombocytopenic purpura: a French retrospective multicenter cohort study
| العنوان: | Type of plasma preparation used for plasma exchange and clinical outcome of adult patients with acquired idiopathic thrombotic thrombocytopenic purpura: a French retrospective multicenter cohort study |
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| المؤلفون: | Toussaint-Hacquard, Marie, Coppo, Paul, Soudant, Marc, Chevreux, Lysiane, Mathieu-Nafissi, Suzanne, Lecompte, Thomas Pierre, Gross, Sylvie, Guillemin, Francis, Schneider, Thierry |
| المصدر: | Transfusion, Vol. 55, No 10 (2015) pp. 2445-51 |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | ddc:616, Adult, Male, Plasma Exchange, Purpura, Thrombotic Thrombocytopenic, Platelet Count, Middle Aged, Disease-Free Survival, Survival Rate, Plasma, hemic and lymphatic diseases, Humans, Female, France, Registries, Retrospective Studies |
| الوصف: | Plasma exchange (PE) is the first-line therapy of acquired thrombotic thrombocytopenic purpura (TTP). Several plasma preparations have been available; their equivalence in terms of outcome remains uncertain.We performed a retrospective analysis of the cases prospectively reported from 2005 to 2010 to the national registry established by the thrombotic microangiopathies French reference center. We analyzed 108 initial episodes of acquired idiopathic TTP in adults treated with PE, 81 with solvent/detergent (S/D) plasma, and 27 with quarantine fresh-frozen plasma (qFFP). The primary endpoint was the time to platelet (PLT) count recovery.Time to PLT count recovery was not significantly different with S/D plasma versus qFFP (median, 15 days vs. 19 days, respectively; p = 0.126). Complete remission rates, exacerbations, and survival were comparable. By multivariate competitive risk (Fine-Gray) analysis, the only significant association with a shorter time to PLT count recovery was the absence of additional treatment (hazard ratio, 2.06; 95% confidence interval [CI], 1.39-3.05; p 0.001). There was a significant interaction between type of plasma and age, and for patients less than 40 years old, the use of S/D plasma was associated with a shorter time to PLT count recovery versus qFFP (median, 13 [95% CI, 9-16] days vs. 20 [95% CI, 16-64] days, respectively; p = 0.004).The outcomes of acquired TTP treated with S/D plasma or qFFP seem similar and therefore both preparations can be used safely for PE in this indication. The faster response of S/D plasma observed in younger patients warrants confirmation in prospective studies. |
| تدمد: | 1537-2995 0041-1132 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bd0c4d0827ab9ab74b3bddc8b2fd1bc6Test https://pubmed.ncbi.nlm.nih.gov/26173755Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.pmid.dedup....bd0c4d0827ab9ab74b3bddc8b2fd1bc6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15372995 00411132 |
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