Transfusion‐transmitted HBV infection in an endemic area: the necessity of more sensitive screening for HBV carriers
| العنوان: | Transfusion‐transmitted HBV infection in an endemic area: the necessity of more sensitive screening for HBV carriers |
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| المؤلفون: | Cha-Ze Lee, Ding-Shinn Chen, Teh-Hong Wang, Pei-Jer Chen, Jin-Town Wang |
| المصدر: | Transfusion. 42:1592-1597 |
| بيانات النشر: | Wiley, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Hepatitis B virus, HBsAg, Blood transfusion, Endemic Diseases, medicine.medical_treatment, Molecular Sequence Data, Immunology, Taiwan, Blood Donors, Antibodies, Viral, Serology, medicine, Humans, Immunology and Allergy, Prospective Studies, Risk factor, Antigens, Viral, Hepatitis B Surface Antigens, Transmission (medicine), business.industry, Blood Screening, Transfusion Reaction, virus diseases, Sequence Analysis, DNA, Hematology, Hepatitis B, Virology, digestive system diseases, DNA, Viral, Viral disease, Complication, business, Follow-Up Studies |
| الوصف: | BACKGROUND : By NAT, HBV DNA is occasionally detectable in blood donors with past HBV infection but negative for HBsAg. Whether or not these donors can cause transfusion-transmitted HBV infections is uncertain. STUDY DESIGN AND METHODS : To determine whether or not donors with past HBV infection but negative for HbsAg can cause HBV transfusion-transmitted infections, recipients followed for blood transfusion in a university medical center in Taiwan were studied. HBV DNA and serologic markers were tested in donors and recipients. RESULTS : Of 1038 enrolled recipients, 910 completed the 6-month post-transfusion follow-up visit. Of these, only 39 patients (4.3%) tested negative on the pretransfusion sample for HBsAg, anti-HBs, anti-HBc, and HBV DNA by PCR. These 39 HBV-naive recipients had been transfused with blood from 147 donations for which stored samples were available for HBV DNA testing by PCR; 11 of these HBsAg-negative samples tested positive for HBV DNA and anti-HBc. Two of the 11 patients who received the HBV-DNA-positive donations (18%) became positive for HBV DNA, and one seroconverted to anti-HBc and finally to anti-HBs, with a mild transient elevation of serum ALT activities. Based on the one confirmed case of HBV transmission, a projection was made that approximately 200 post-transfusion HBV infections could occur in one million units of transfused blood in Taiwan. CONCLUSIONS : In HBV-endemic areas like Taiwan, where blood donors are screened for HBsAg only, the risk of transfusion-transmitted HBV appears to be substantial. Implementation of NAT for blood screening in these settings warrants consideration. |
| تدمد: | 1537-2995 0041-1132 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b66f238d7904da51563e246ab3c1233Test https://doi.org/10.1046/j.1537-2995.2002.00274.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....8b66f238d7904da51563e246ab3c1233 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15372995 00411132 |
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