CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non‐Hodgkinʼs lymphoma patients: results of the prospective multicenter GOA study
| العنوان: | CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non‐Hodgkinʼs lymphoma patients: results of the prospective multicenter GOA study |
|---|---|
| المؤلفون: | Marja Pyörälä, Esa Jantunen, Kaija Vasala, Hanne Kuitunen, Ville Varmavuo, Jukka Pelkonen, Pentti Mäntymaa, Outi Kuittinen, Antti Turunen, Antti Ropponen, Mervi Putkonen, Anu Partanen, Leena Keskinen, Taru Kuittinen, Eeva-Riitta Savolainen, Jaakko Valtola, Timo Siitonen, Marja Sankelo, Raija Silvennoinen, Karri Penttilä, Anu Sikiö |
| المساهمون: | Department of Oncology, HUS Comprehensive Cancer Center, HYKS erva, Hematologian yksikkö, Kymsote – Social and Health Services in Kymenlaakso |
| المصدر: | Transfusion. 60:1519-1528 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Benzylamines, IMPACT, Antigens, CD34, 030204 cardiovascular system & hematology, Cyclams, Gastroenterology, PLUS G-CSF, 0302 clinical medicine, Autologous stem-cell transplantation, immune system diseases, hemic and lymphatic diseases, CYCLOPHOSPHAMIDE, Immunology and Allergy, Prospective Studies, Autografts, Prospective cohort study, Multiple myeloma, Lymphoma, Non-Hodgkin, Hematology, Middle Aged, Hematopoietic Stem Cell Mobilization, Survival Rate, Female, Multiple Myeloma, medicine.drug, Adult, medicine.medical_specialty, Cyclophosphamide, 3122 Cancers, Immunology, Disease-Free Survival, PLERIXAFOR, 03 medical and health sciences, Internal medicine, medicine, Humans, POOR MOBILIZATION, Survival rate, Aged, Peripheral Blood Stem Cell Transplantation, business.industry, MORTALITY, Plerixafor, STEM-CELL TRANSPLANTATION, 3126 Surgery, anesthesiology, intensive care, radiology, medicine.disease, Lymphoma, HEMATOPOIETIC STEM, VOLUME, Peripheral Blood Stem Cells, RISK-FACTORS, business, 030215 immunology |
| الوصف: | BACKGROUND Autologous stem cell transplantation is an established treatment option for patients with multiple myeloma (MM) or non-Hodgkin?s lymphoma (NHL). STUDY DESIGN AND METHODS In this prospective multicenter study, 147 patients with MM were compared with 136 patients with NHL regarding the mobilization and apheresis of blood CD34+ cells, cellular composition of infused blood grafts, posttransplant recovery, and outcome. RESULTS Multiple myeloma patients mobilized CD34+ cells more effectively (6.3???106/kg vs. 3.9???106/kg, p?=?0.001). The proportion of poor mobilizers (peak blood CD34+ cell count 100?days) nonrelapse mortality (NRM; 6% vs. 0%, p?=?0.003). CONCLUSIONS Non-Hodgkin?s lymphoma and MM patients differ in terms of mobilization of CD34+ cells, graft cellular composition, and posttransplant recovery. Thus, the optimal graft characteristics may also be different. |
| تدمد: | 1537-2995 0041-1132 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4122c64b23b6ebdd5ad3ae7826e6f4Test https://doi.org/10.1111/trf.15820Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....da4122c64b23b6ebdd5ad3ae7826e6f4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15372995 00411132 |
|---|