Continued reassortment of avian H6 influenza viruses from Southern China, 2014–2016
| العنوان: | Continued reassortment of avian H6 influenza viruses from Southern China, 2014–2016 |
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| المؤلفون: | Tao Hu, Quanjiao Chen, Yifei Nie, Jianjun Chen, Yuhai Bi, George F. Gao, Changwen Ke, Juan Li, Yingxia Liu, Chuansong Quan, William J. Liu, Luzhao Feng, Weifeng Shi, Yun Xie, Qianli Wang, Wenjun Liu, Hongjie Yu, Gary Wong |
| المصدر: | Transboundary and Emerging Diseases. 66:592-598 |
| بيانات النشر: | Hindawi Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | China, Lineage (genetic), Genotype, 040301 veterinary sciences, Reassortment, Biology, Poultry, 0403 veterinary science, 03 medical and health sciences, Animals, Longitudinal Studies, Clade, Phylogeny, Poultry Diseases, 030304 developmental biology, 0303 health sciences, Avian influenza virus, General Veterinary, General Immunology and Microbiology, Phylogenetic tree, Strain (biology), 04 agricultural and veterinary sciences, General Medicine, Virology, Ducks, Southern china, Influenza A virus, Influenza in Birds, Reassortant Viruses |
| الوصف: | H6 subtype avian influenza virus (AIV) was prevalent in poultry and could sporadically infect humans. Here, a total of 196 novel H6 AIVs isolated from poultry in eight provinces of China from 2014 to 2016 were phylogenetically characterized. Our analysis revealed that they could be divided into two clades in the Asian H6 HA lineage, A/wild duck/Shantou/2853/2003(H6N2) (ST2853-like) (85.7%) and A/duck/Shantou/339/2000(H6N2) (ST339-like) (14.3%), in which ST2853-like strains predominate. These novel strains belonged to the H6N6 (n = 165, 84.2%), H6N2 (n = 30, 15.3%), and H6N3 (n = 1, 0.51%) subtypes, which could be classified into 36 genotypes including 12 novel genotypes described in this study. In particular, several strains possessed the V190 and S228 mutations in HA (H3 numbering), which is critical for human receptor binding and identical to the human-derived strain A/Taiwan/2/2013(H6N1). Furthermore, 10.3% of the H6N6 isolates possessed the N6-∆11b (59-69) deletion. In summary, we describe phylogenetic and molecular characterizations of H6 AIVs in southern China and highlight the constant prevalence of H6 AIVs in poultry as well as adaptation to mammalian hosts. |
| تدمد: | 1865-1682 1865-1674 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685d8aec7d5f19f10d21247ab0c56200Test https://doi.org/10.1111/tbed.13037Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....685d8aec7d5f19f10d21247ab0c56200 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18651682 18651674 |
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