Anti-Inflammatory and Immune Regulatory Actions of Naja naja atra Venom
| العنوان: | Anti-Inflammatory and Immune Regulatory Actions of Naja naja atra Venom |
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| المؤلفون: | Zheng-Hong Qin, Shu-Zhi Wang |
| المصدر: | Toxins Toxins, Vol 10, Iss 3, p 100 (2018) |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | rheumatoid arthritis, 0301 basic medicine, Cellular immunity, medicine.drug_class, Health, Toxicology and Mutagenesis, T lymphocytes, Anti-Inflammatory Agents, lcsh:Medicine, Inflammation, Venom, Review, Pharmacology, Toxicology, NF-κB, Anti-inflammatory, 03 medical and health sciences, chemistry.chemical_compound, Immune system, systemic lupus erythematosus, nephritis, Immunity, medicine, pneumonia, Animals, Humans, Immunologic Factors, complement system, Elapid Venoms, cobra venom, allograft rejection, business.industry, lcsh:R, immune regulation, Naja naja, anti-inflammation, In vitro, 030104 developmental biology, chemistry, medicine.symptom, business |
| الوصف: | Naja naja atra venom (NNAV) is composed of various proteins, peptides, and enzymes with different biological and pharmacological functions. A number of previous studies have reported that NNAV exerts potent analgesic effects on various animal models of pain. The clinical studies using whole venom or active components have confirmed that NNAV is an effective and safe medicine for treatment of chronic pain. Furthermore, recent studies have demonstrated that NNAV has anti-inflammatory and immune regulatory actions in vitro and in vivo. In this review article, we summarize recent studies of NNAV and its components on inflammation and immunity. The main new findings in NNAV research show that it may enhance innate and humoral immune responses while suppressing T lymphocytes-mediated cellular immunity, thus suggesting that NNAV and its active components may have therapeutic values in the treatment of inflammatory and autoimmune diseases. |
| تدمد: | 2072-6651 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10da8af7985074382763bd79c7f19378Test https://doi.org/10.3390/toxins10030100Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....10da8af7985074382763bd79c7f19378 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726651 |
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