Nigella sativa oil protects against tartrazine toxicity in male rats
| العنوان: | Nigella sativa oil protects against tartrazine toxicity in male rats |
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| المؤلفون: | Mazin A. Zamazami, Amani Mohammed Al-Hamed, Haddad A. El Rabey, Madeha N. Al-Seeni |
| المصدر: | Toxicology Reports, Vol 5, Iss, Pp 146-155 (2018) Toxicology Reports |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Health, Toxicology and Mutagenesis, 010501 environmental sciences, Pharmacology, Kidney, Toxicology, G3, the third group (G3) received 10 mg/kg b.w. tartrazine and 3.75 mg/kg b.w. sulfanilic acid and cotreated with 10 ml/kg body weight Nigella sativa oil for 8 weeks, 01 natural sciences, LDL, low density lipoprotein, Lipid peroxidation, chemistry.chemical_compound, 0302 clinical medicine, AST, serum aspartate aminotransferase, Nigella sativa, G2, the second positive control group fed diets containing 10 mg/kg b.w. tartrazine and 3.75 mg/kg b.w. sulfanilic acid, Tartrazine, TG, triglyceride, Stomach, food and beverages, B.W., body weight, Honey, Food additives, medicine.anatomical_structure, Liver, 030220 oncology & carcinogenesis, Toxicity, G1, the first negative control untreated group fed basal diet containing 3.75 mg/kg b.w. sulfanilic acid, BWG, body weight gain, Renal function, FER, food efficiency ratio, Article, ALT, serum alanine aminotransferase, 03 medical and health sciences, lcsh:RA1190-1270, medicine, Adverse effect, ComputingMethodologies_COMPUTERGRAPHICS, 0105 earth and related environmental sciences, lcsh:Toxicology. Poisons, MDA, malondialdehyde, VLDL, very low density lipoproteins, business.industry, TC, total cholesterol, chemistry, ALP, serum alkaline phosphatase, Rat, business, N.N cellulose, non-nutritive cellulose |
| الوصف: | Graphical abstract Highlights • Tartrazine caused kidney and liver dysfunction. • Kidney and liver function parameters and the histopathogy of the examined sections were altered. • The concurrent treatment by N. sativa oil improved biochemical parameters. • The concurrent treatment by N. sativa oil restored the histology of kidney, testis, liver and stomach to normal. This study aimed to evaluate the protective role of Nigella sativa oil against the adverse effects of tartrazine on male rats. 18 albino rats were divided randomly into four groups (n = 6). The first (G1) is the negative control, the second group (G2) is the positive control received 10 mg/kg b.w. tartrazine in the diet and the third (G3) received the same dose of tartrazine as in G2 and co-treated with Nigella sativa oil for 8 weeks. Tartrazine decreased total protein, antioxidants and high density lipoproteins, whereas increased liver enzyme, kidney function parameters, total cholesterol, triglycerides, low density lipoproteins and lipid peroxidation in the positive control group. In addition, it caused pathological changes in the tissues of liver, kidney, testes and stomach. Treating tartrazine supplemented rats of G3 with Nigella sativa oil for 8 weeks significantly improved all biochemical parameters and restored the tissues of kidney, stomach, testes and liver to normal. It could be concluded that N. sativa oil succeeded in protecting male rats against the adverse conditions resulted from tartrazine administration. |
| اللغة: | English |
| تدمد: | 2214-7500 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5634eadd32501d010da195dbeb2c4fdaTest http://www.sciencedirect.com/science/article/pii/S2214750017301373Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5634eadd32501d010da195dbeb2c4fda |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22147500 |
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