The HLA-DQβ non-Asp-57 allele: a predictor of future insulin-dependent diabetes mellitus in patients with autoimmune Addison's disease
| العنوان: | The HLA-DQβ non-Asp-57 allele: a predictor of future insulin-dependent diabetes mellitus in patients with autoimmune Addison's disease |
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| المؤلفون: | Bernhard O. Boehm, C. Rosak, K. Schöffling, Massimo Trucco, S. Seidl, B. Manfras, G. Holzberger, Kühnl P |
| المصدر: | Tissue Antigens. 37:130-132 |
| بيانات النشر: | Wiley, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | endocrine system, medicine.medical_specialty, endocrine system diseases, Molecular Sequence Data, Immunology, Immunogenetics, Human leukocyte antigen, Disease, Biochemistry, Autoimmune Diseases, HLA-DR3 Antigen, Addison Disease, Risk Factors, immune system diseases, HLA-DQ Antigens, Internal medicine, Diabetes mellitus, Genetics, medicine, HLA-DQ beta-Chains, Humans, Immunology and Allergy, Allele, Alleles, Autoimmune disease, Base Sequence, business.industry, nutritional and metabolic diseases, General Medicine, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, Haplotypes, Relative risk, Insulin dependent diabetes, business |
| الوصف: | HLA-DR specificities in 72 Addison's (AD) patients and 808 local controls were compared. We confirmed earlier reports that the HLA-DR3 specificity is significantly increased in AD patients. In our study a relative risk of 3.4 chi 2 = 22.5; pc = 0.01) for the disease was calculated. Analysis of HLA-DQB1 alleles in DR4+ Addison's patients with diabetes mellitus (N = 6) and without IDDM (14 of 18 individuals tested) revealed that the HLA-DQw8 allele (DQB1*0302) was significantly increased in AD patients with IDDM (chi 2 = 13.5; p = 0.001); conversely, a clustering of the HLA-DQw7 allele was detected in DR4+ Addison's patients without IDDM. We thus conclude that particular polymorphic alleles corresponding to non-charged amino acids at position 57 of the HLA-DQ beta-chain [non-Asp-57 alleles] are associated with IDDM also in Addison's patients. |
| تدمد: | 1399-0039 0001-2815 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a305fde3ab0890d1dd5fae58d007bdTest https://doi.org/10.1111/j.1399-0039.1991.tb01858.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....17a305fde3ab0890d1dd5fae58d007bd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13990039 00012815 |
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