دورية
Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study
| العنوان: | Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study |
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| المؤلفون: | Nathan, Nadia, Montagne, Marie-Emeline, Macchi, Odile, Rosental, Paul-André, Chauveau, Simon, Jeny, Florence, Sesé, Lucile, Abou Taam, Rola, Brocvielle, Manon, Brouard, Jacques, Catinon, Mickae¨l, Chapelon-Abric, Catherine, Cohen-Aubart, Fleur, Delacourt, Christophe, Delestrain, Céline, Deschildre, Antoine, Dossier, Antoine, Epaud, Ralph, Haroche, Julien, Houdouin, Véronique, Israel-Biet, Dominique, Juvin, Karine, Le Jeune, Sylvain, Lionnet, Francois, Meinzer, Ulrich, Mittaine, Marie, Nunes, Hilario, Mattioni, Sarah, Naccache, Jean-Marc, Odièvre, Marie-Hélène, Vincent, Michel, Clement, Annick, Valeyre, Dominique, Cavalin, Catherine |
| المصدر: | Thorax; 2022, Vol. 77 Issue: 4 p404-407, 4p |
| مستخلص: | Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients’ indirect exposure to inorganic particles, through coresidents’ occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5–7) vs 0.5 (0–2), p=0.003 and 1 (0–2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00406376 14683296 |
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| DOI: | 10.1136/thoraxjnl-2021-217870 |