Correlation between CXCR4, CXCR5 and CCR7 expression and survival outcomes in patients with clinical T1N0M0 non‐small cell lung cancer
| العنوان: | Correlation between CXCR4, CXCR5 and CCR7 expression and survival outcomes in patients with clinical T1N0M0 non‐small cell lung cancer |
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| المؤلفون: | Ding Ningning, Mao Yousheng, Yang Lin, Zhao Yue, Zhang Hongtu, Yuan Ligong, Li Feng, Ying Jianming, Wang Shuaibo |
| المصدر: | Thoracic Cancer, Vol 11, Iss 10, Pp 2955-2965 (2020) Thoracic Cancer |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Receptors, CXCR5, 0301 basic medicine, Pulmonary and Respiratory Medicine, non‐small cell lung cancer, Receptors, CCR7, Receptors, CXCR4, medicine.medical_specialty, survival outcome, Lung Neoplasms, Multivariate analysis, C-C chemokine receptor type 7, Gastroenterology, CXCR4, lcsh:RC254-282, CXCR5, Correlation, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Internal medicine, medicine, Humans, Lung cancer, Survival analysis, Aged, Neoplasm Staging, Retrospective Studies, business.industry, Original Articles, General Medicine, Middle Aged, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Immunohistochemistry, Female, Original Article, business, CCR7 |
| الوصف: | Background Lung cancer is the leading cause of cancer‐related death. Even if early detection and treatment have proven to be effective, the survival outcomes are still poor. Methods Tissue samples and clinicopathological data of 244 patients with clinical T1N0M0 NSCLC were collected. We investigated CXCR4, CXCR5 and CCR7 expression levels using the immunohistochemical method and analyzed their correlations with clinicopathological characteristics and survival outcomes. Results Elevated expression levels of CXCR4, CXCR5 and CCR7 were found in tumor tissues (P Expression levels of CXCR4, CXCR5 and CCR7 were significantly higher in tumor tissues, and expression of CXCR5 and CCR7 were independent prognostic factors for survival. Moreover, all three chemokines were correlated to the survival outcomes of patients with clinical T1N0M0 NSCLC, providing potential prognosticators and therapy targets for lung cancer treatment. |
| اللغة: | English |
| تدمد: | 1759-7706 1759-7714 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558273cd694a111e7d6381e6baf7e702Test https://doaj.org/article/78e8a5eff5d748cf9cbff5c7118d5475Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....558273cd694a111e7d6381e6baf7e702 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17597706 17597714 |
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