التفاصيل البيبلوغرافية
| العنوان: |
Morphometric and mechanical characterization of thoracic aorta ; Caractérisations morphométriques et biomécaniques de l'aorte thoracique |
| المؤلفون: |
Boufi, Mourad |
| المساهمون: |
Aix-Marseille, Alimi, Yves, Deplano, Valérie |
| المصدر: |
Theses.fr |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
Endoprothèses, Aorte thoracique, Complications, Propriétés mécaniques, Aorte porcine, Dissection aortique, Stent-Grafts, Thoracic aorta, Mechanical properties, Swine aorta, Aortic dissection, envir, geo |
| الوصف: |
Objectives: characterize (1) arch morphometry to examine criteria favoring complications after thoracic endovascular aortic repair (TEVAR) and feasibility of « off-the-shelf » fenestrated devices.(2) mechanical properties of ascending aorta (AA) in swine and humans, with and without aortic dissection.Materials and methods : Morphometric characterization : Computed tomographic angiography were analysed to calculate elementary morphometric, geometric and supra-aortic trunks data Mechanical characterization : In vivo: arterial pressure and diameters measured with echocardiophy are used to calculate elastic parameters.Ex vivo: biaxial tensile testing performed on AA plus histological and microstructural analysis. Results :Morphometric characterization : In > 75% of cases supra-aortic branches are positioned within 15° of each other and distances between them have a variability of ± 4 mm.Independant factors associated with endoleak, bird beak and mis-positioning are respectively : (1) short proximal neck (2) landing zone angulation (cut-off value: 51°); and (3) tortuosity index (cut-off value: 1.68). Mechanical characterization : in vivo: greater compliance of swine aorta compared to humans and a stiffer aorta in case of aortic dissectionBiaxial testing: linear stress-strain behavior of swine aorta, compared to a non linear one in human. Conclusion : our study reveals :- the impact of anatomy on complications occurrence after TEVAR, and suitable arguments for « off-the-shelf » fenestrated devices.- swine model is inappropriate to test AA dedicated stent-graft.- stiffer wall in aortic dissection has consequences on the choice of futur devices dedicated to AA. ; Objectifs : caractériser (1) la morphométrie de la crosse afin d’examiner les critères favorisant les complications et la faisabilité d’endoprothèses (EP) standards. (2) les propriétés mécaniques de l’aorte ascendante (AA) chez le porc, homme sain et en cas de dissection aortique (DAo).Matériels et méthodes :Caractérisation morphométrique : A partir ... |
| نوع الوثيقة: |
thesis |
| اللغة: |
French |
| العلاقة: |
10670/1.f2mdyo; http://www.theses.fr/2016AIXM5000Test |
| الإتاحة: |
http://www.theses.fr/2016AIXM5000Test |
| حقوق: |
other |
| رقم الانضمام: |
edsbas.BFB755D9 |
| قاعدة البيانات: |
BASE |
