التفاصيل البيبلوغرافية
| العنوان: |
Multimodal assessement of neurogenic lower urinary tract dysfunction in spina bifida patients ; Evaluation multimodale du régime de pression vésicale chez les patients spina bifida |
| المؤلفون: |
Peyronnet, Benoit |
| المساهمون: |
Rennes 1, Bouguen, Guillaume, Game, Xavier |
| المصدر: |
Theses.fr |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
Spina bifida, Biomarqueurs urinaires, Radiomique, Dysfonction neurogène bas appareil urinaire, Urodynamique, Compliance vésicale, Urinary biomarkers, Radiomics, Neurogenic lower urinary tract dysfunction, Urodynamics, Bladder compliance, demo, socio |
| الوصف: |
Aims : To describe neurognenic lower urinary tract dysfunctions (NLUTD) in spina bifida patients, their impact on mortality and the role of alternatives to urodynamics in evaluating NLUTD in this patients’ population. Methods: A prospective cohort was used to describe NLUTD in spina bifida patients and a nationwide epidemiological study was performed to assess the proportion of urological causes in the overall mortality of this population. A prospective study was conducted to evaluate the role of urinary biomarkers and radiomics in the assessement of bladder pressure in spina bifida patients. Results: There is a high prevalence of low bladder compliance and high bladder pressure in spina bifida patients. Urological disorders are the leading cause of death in spina bifida patients in France nowadays. Urinary levels of TIMP-2 and MMP-2 are associated with low compliance bladder and urinary TIMP-2 has diagnostic performances slightly superior to urodynamics for upper urinary tract damage. Markers of extracellular matrix remodeling such as TGFβ-1 differ between spina bifida and other neurological conditions in case of NDO. Radiomics, especially CT texture parameters is associated with several urodynamic parameters and might help to evaluate bladder pressures in spina bifida patients. Conclusion: Spina bifida NLUTD are singular and severe, with strong implication of extracellular matrix remodeling. Multimodal evaluation of spina bifida NLUTD including urinary biomarkers and radiomics might help to optimize the management of these patients. ; Objectifs : Décrire les spécificités des troubles vésico-sphinctériens des patients spina bifida, leur impact sur la mortalité et l’intérêt d’outils diagnostiques alternatifs à l’urodynamique pour l’évaluation du régime de pression vésicale dans cette population. Méthodes : une cohorte prospective a été utilisée pour décrire les troubles vésico-sphinctériens des patients spina bifida et une étude épidémiologique nationale sur la base PMSI a été effectuée pour évaluer ... |
| نوع الوثيقة: |
thesis |
| اللغة: |
French |
| العلاقة: |
10670/1.49qqa4; http://www.theses.fr/2019REN1B031Test |
| الإتاحة: |
http://www.theses.fr/2019REN1B031Test |
| حقوق: |
other |
| رقم الانضمام: |
edsbas.F7A154AD |
| قاعدة البيانات: |
BASE |
