التفاصيل البيبلوغرافية
| العنوان: |
Fulminant Peritonitis Presumably Caused by Panton-Valentine Leukocidin-Positive Staphylococcus aureus in a Girl on Peritoneal Dialysis. |
| المؤلفون: |
Battelino, Nina, Pokorn, Marko, Švent‐Kučina, Nataša, Križan‐Hergouth, Veronika, Novljan, Gregor |
| المصدر: |
Therapeutic Apheresis & Dialysis; Aug2013, Vol. 17 Issue 4, p431-437, 7p, 1 Black and White Photograph, 1 Chart |
| مستخلص: |
Peritonitis is a significant complication of peritoneal dialysis ( PD) and the most common cause of technique failure. Panton-Valentine leukocidin ( PVL), a cytotoxin produced by certain strains of Staphylococcus aureus ( SA), causes destruction of neutrophils, and is associated with severe invasive infections. We present a 2.5-year-old girl on PD, who presented suddenly with an unusually fulminant and protracted course of peritonitis. Only a few hours after the onset of clinical signs, septic shock developed. PVL-positive methicillin-sensitive SA ( MSSA) was grown and initial empiric antibiotic treatment changed to flucloxacillin and rifampicin in order to minimize toxin production. In spite of adequate antibiotic treatment and PD-catheter removal, recovery was slow. No PD-related peritonitis in children associated with PVL-producing strains have been reported so far and no specific recommendation exists for treatment. We speculate that PVL contributed to the severity and outcome of peritonitis in our patient. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
