D-methionine alleviates cisplatin-induced mucositis by restoring the gut microbiota structure and improving intestinal inflammation
العنوان: | D-methionine alleviates cisplatin-induced mucositis by restoring the gut microbiota structure and improving intestinal inflammation |
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المؤلفون: | Chu-Chyn Ou, Jiuan-Miaw Liao, Jiunn-Liang Ko, Ling-Hui Lee, Li-Yu Chang, Shiang-Suo Huang, Meei-Yn Lin, Cheng-Hsi Wu |
المصدر: | Therapeutic Advances in Medical Oncology Therapeutic Advances in Medical Oncology, Vol 11 (2019) |
بيانات النشر: | SAGE Publications, 2019. |
سنة النشر: | 2019 |
مصطلحات موضوعية: | Cisplatin, biology, business.industry, gastrointestinal mucositis, Gastrointestinal mucositis, cisplatin, Gut flora, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, biology.organism_classification, lcsh:RC254-282, D methionine, D-methionine, Lactobacillus, Oncology, Intestinal inflammation, Immunology, medicine, Mucositis, next-generation sequencing, business, Dysbiosis, Original Research, medicine.drug |
الوصف: | Background: There are close links between chemotherapy-induced intestinal mucositis and microbiota dysbiosis. Previous studies indicated that D-methionine was an excellent candidate for a chemopreventive agent. Here, we investigated the effects of D-methionine on cisplatin-induced mucositis. Materials and methods: Male Wistar rats (176–200 g, 6 weeks old) were given cisplatin (5 mg/kg) and treated with D-methionine (300 mg/kg). Histopathological, digestive enzymes activity, oxidative/antioxidant status, proinflammatory/anti-inflammatory cytokines in intestinal tissues were measured. Next-generation sequencing technologies were also performed to investigate the gut microbial ecology. Results: D-methionine administration increased villus length and crypt depth and improved digestive enzyme (leucine aminopeptidase, sucrose and alkaline phosphatase) activities in the brush-border membrane of cisplatin-treated rats ( p < 0.05). Furthermore, D-methionine significantly attenuated oxidative stress and inflammatory reaction and increased interleukin-10 levels in cisplatin-induced intestinal mucositis ( p < 0.05). Cisplatin administration resulted in high relative abundances of Deferribacteres and Proteobacteria and a low diversity of the microbiota when compared with control groups, D-methionine only and cisplatin plus D-methionine. Cisplatin markedly increased comparative abundances of Bacteroides caccae, Escherichia coli, Mucispirillum schaedleri, Bacteroides uniformis and Desulfovibrio C21-c20, while Lactobacillus was almost completely depleted, compared with the control group. There were higher abundances of Lactobacillus, Lachnospiraceae, and Clostridium butyrium in cisplatin plus D-methionine rats than in cisplatin rats. D-methionine treatment alone significantly increased the number of Lactobacillus reuteri. Conclusion: D-methionine protects against cisplatin-induced intestinal damage through antioxidative and anti-inflammatory effects. By enhancing growth of beneficial bacteria (Lachnospiraceae and Lactobacillus), D-methionine attenuates gut microbiome imbalance caused by cisplatin and maintains gut homeostasis. |
تدمد: | 1758-8359 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8774f725085389dc2d3a5a6b5a362e17Test https://doi.org/10.1177/1758835918821021Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....8774f725085389dc2d3a5a6b5a362e17 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 17588359 |
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