دورية
Simulating Probability Distributions in the Coalescent
| العنوان: | Simulating Probability Distributions in the Coalescent |
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| المؤلفون: | Griffiths, R.C., Tavare, S. |
| المصدر: | Theoretical Population Biology; October 1994, Vol. 46 Issue: 2 p131-159, 29p |
| مستخلص: | We describe some computational algorithms for computing probability distributions for sample configurations from the finite-sites models in population genetics. One particular interest is the development of computational methods for estimating substitution rates for DNA sequence data using likelihood techniques. The approach uses a recursion satisfied by the sampling probabilities to construct a Markov chain with a set of absorbing states in such a way that the required sampling distribution is the mean of a functional of the process up to the absorption time. This provides a conceptually simple framework for simulating the likelihood of the data for a set of parameter values. The method is particularly attractive in practice: it is simple to program and can be extended to cover other features of interest such as the infinitely-many-sites process, recombination, selection, and variable population size.Copyright 1994, 1999 Academic Press, Inc. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00405809 10960325 |
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| DOI: | 10.1006/tpbi.1994.1023 |