Interleukin-10 gene promoter polymorphism in patients with schizophrenia in a region of East Turkey
| العنوان: | Interleukin-10 gene promoter polymorphism in patients with schizophrenia in a region of East Turkey |
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| المؤلفون: | Esra Tug, Mustafa Namli, Ulku Ozbey |
| المصدر: | The World Journal of Biological Psychiatry. 10:461-468 |
| بيانات النشر: | Informa UK Limited, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Genetic Markers, Male, Genotype, Turkey, Schizophrenia (object-oriented programming), Population, Biology, behavioral disciplines and activities, Young Adult, Gene Frequency, Polymorphism (computer science), mental disorders, Humans, Genetic Predisposition to Disease, Allele, Promoter Regions, Genetic, education, Alleles, Biological Psychiatry, Genetics, education.field_of_study, Polymorphism, Genetic, Homozygote, Haplotype, Promoter, Middle Aged, Interleukin-10, Psychiatry and Mental health, Genetics, Population, Haplotypes, Chromosomes, Human, Pair 1, Schizophrenia, Female, Restriction fragment length polymorphism, Polymorphism, Restriction Fragment Length |
| الوصف: | Schizophrenia is one of the most severe psychiatric disorders, with a worldwide incidence of 1%. Immunological abnormalities have been found to be associated with schizophrenia for decades. Cytokines are key proteins involved in the immune system activation. Interleukin-10 (IL-10), an important immunoregulatory cytokine, is located on chromosome 1q31 32, a region previously reported to be linked to schizophrenia in genetic studies. In the present study it was aimed to examine the IL-10 gene promoter region's polymorphic variants in patients with schizophrenia in a population of the Elazig Region of East Anatolia, Turkey. Polymorphisms at position -1082, -819 and -592 in the IL-10 promoter region were determined in 171 Turkish patients who were diagnosed with schizophrenia, based on the DSM-IV, and 168 healthy controls, by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). We analyzed allele, genotype, and haplotype distributions using a case-control association study. Genotyping was performed by RFLP. Statistically significant differences were observed in both allelic and genotypic frequencies of the -592A/C polymorphism (Allele, P = 0.034, OR = 1.26, 95% CI 1.02 - 1.56; Genotype, P = 0.048), while the other two polymorphisms in distribution of the alleles and genotypes in patients with schizophrenia were not significantly different from those of controls (P > 0.05). Our results show a significant increase of GTA homozygotes (the high IL-10-producing haplotype) in schizophrenic patients compared to control subjects (P = 0.0001). These data suggest that the IL-10 gene promoter polymorphism may be one of the susceptibility factors to develop schizophrenia in the Turkish population, and apparently in all humans. |
| تدمد: | 1814-1412 1562-2975 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1461d2cd2156e3f4da457540d08ace38Test https://doi.org/10.1080/15622970802626580Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1461d2cd2156e3f4da457540d08ace38 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18141412 15622975 |
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