DJ-1 as a Modulator of Autophagy: An Hypothesis
| العنوان: | DJ-1 as a Modulator of Autophagy: An Hypothesis |
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| المؤلفون: | Rosa A. González-Polo, Mireia Niso-Santano, José M. Fuentes, José Manuel Bravo-San Pedro, Rubén Gómez-Sánchez |
| المصدر: | The Scientific World Journal, Vol 10, Pp 1574-1579 (2010) The Scientific World Journal |
| بيانات النشر: | Hindawi Limited, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Paraquat, DJ-1, autophagy, Programmed cell death, Protein Deglycase DJ-1, lcsh:Medicine, Apoptosis, Caspase 3, Biology, Models, Biological, lcsh:Technology, General Biochemistry, Genetics and Molecular Biology, Pathogenesis, Neuroblastoma, chemistry.chemical_compound, Cell Line, Tumor, medicine, Humans, lcsh:Science, Sensitization, General Environmental Science, Membrane Potential, Mitochondrial, Oncogene Proteins, Herbicides, lcsh:T, Adenine, lcsh:R, Autophagy, Intracellular Signaling Peptides and Proteins, neurodegeneration, Cytochromes c, General Medicine, Cell biology, Enzyme Activation, medicine.anatomical_structure, chemistry, Parkinson’s disease, RNA Interference, lcsh:Q, Reactive Oxygen Species, Directions in Science |
| الوصف: | The etiology of Parkinson's disease (PD) is not completely defined, although environmental factors (for example, exposure to the herbicide paraquat [PQ]) and genetic susceptibility (such as DJ-1 mutations that have been associated with an autosomal-recessive form of early-onset PD) have been demonstrated to contribute. Alterations in macroautophagy have been described in the pathogenesis of this neurodegenerative disease. We have established a model system to study the involvement of the DJ-1 protein in PQ-induced autophagy. When we transfected cells exposed to PQ with DJ-1–specific siRNA, we observed an inhibition of the autophagic events induced by the herbicide, as well as sensitization additive with PQ-induced apoptotic cell death and exacerbation of this cell death in the presence of the autophagy inhibitor 3-methyladenine. These results suggest, for the first time, an active role for DJ-1 in the autophagic response produced by PQ, opening the door to new strategies for PD therapy. |
| تدمد: | 1537-744X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26207e5b34f55ebc031395ae58368eb2Test https://doi.org/10.1100/tsw.2010.165Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....26207e5b34f55ebc031395ae58368eb2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1537744X |
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