Polymorphisms in the ABC drug transporter gene MDR1
| العنوان: | Polymorphisms in the ABC drug transporter gene MDR1 |
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| المؤلفون: | Michel Eichelbaum, U Brinkmann |
| المصدر: | The Pharmacogenomics Journal. 1:59-64 |
| بيانات النشر: | Springer Science and Business Media LLC, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Drug, media_common.quotation_subject, Drug Resistance, Biological Availability, Biology, Pharmacology, Mice, Genetic variation, Genetics, Animals, Humans, Gene, media_common, P-glycoprotein, Mice, Knockout, Polymorphism, Genetic, Genetic Variation, Bioavailability, Knockout mouse, biology.protein, Molecular Medicine, Efflux, Genes, MDR, Pharmacogenetics |
| الوصف: | In addition to genetically variable metabolic enzymes such as Cyp p450 proteins, blood and tissue levels of many drugs are influenced by controlled transport across compartmental boundaries. Major determinants in these transport processes are ATP-dependent efflux pumps such as P-glycoprotein and related proteins (eg MRPs), which can influence the bioavailability and CNS concentrations, as well as disposition of drugs. In addition to its recognized role in the development of multiple chemotherapy resistances, experimental evidence for the relevant influence of the MDR1 gene encoded P-glycoprotein, on the pharmacology of many other drugs has been gathered by the analyses of knockout mice, as well as in clinical studies. Recently, functional genetic polymorphisms in the MDR1 gene have been identified which influence the distribution and bioavailability of PGP substrates. |
| تدمد: | 1473-1150 1470-269X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c097e00dfe03c7b3b97368632710f0f3Test https://doi.org/10.1038/sj.tpj.6500001Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c097e00dfe03c7b3b97368632710f0f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14731150 1470269X |
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