Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort
| العنوان: | Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort |
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| المؤلفون: | James Bluett, John Isaacs, Steven Young-Min, Nicholas Hopkinson, Wan-Fai Ng, Karim Raza, William Dixon, Ann Morgan, Fraser Birrell, Anne Barton, Hector Chinoy, Jon Packham, Kimme Hyrich, Raj Sengupta |
| المصدر: | The Pharmacogenomics Journal |
| بيانات النشر: | Nature Publishing Group, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | musculoskeletal diseases, rheumatoid arthritis, Adult, Male, Complement receptor 1, Single-nucleotide polymorphism, Immunogenetics, Blood Sedimentation, Polymorphism, Single Nucleotide, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, tumour necrosis factor-alpha, Genotype, Genetics, medicine, Humans, 030212 general & internal medicine, skin and connective tissue diseases, Aged, 030203 arthritis & rheumatology, Pharmacology, medicine.diagnostic_test, biology, business.industry, Tumor Necrosis Factor-alpha, C-reactive protein, Genomics, Middle Aged, medicine.disease, 3. Good health, immunogenetics, Europe, C-Reactive Protein, Treatment Outcome, Erythrocyte sedimentation rate, Rheumatoid arthritis, Immunology, Cohort, biology.protein, Receptors, Complement 3b, Molecular Medicine, Original Article, Female, biology.gene, business |
| الوصف: | Eligibility for anti-tumour necrosis factor (TNF) therapy in most European countries is restricted to severe, active rheumatoid arthritis (RA). The DAS28 score is a marker of disease severity and incorporates one of two inflammatory markers, erythrocyte sedimentation rate (ESR) or C-reactive protein. We aimed to determine the relation between genetic variants known to affect ESR and levels of ESR in patients with active RA. DNA samples were genotyped for four single-nucleotide polymorphisms (SNPs) rs7527798 (CR1L), rs6691117 (CR1), rs10903129 (TMEM57) and rs1043879 (C1orf63). The association between SNPs and baseline ESR, baseline DAS28-ESR, and change in DAS28-ESR was evaluated. Baseline ESR was significantly associated with CR1 rs6691117 genotype (P=0.01). No correlation was identified between baseline DAS28-ESR or change in DAS28-ESR. In conclusion, genetic variation in the gene encoding CR1 may alter ESR levels but not DAS28-ESR, indicating no adjustment for CR1 genotype is required in the assessment of patients with severe active RA. |
| اللغة: | English |
| تدمد: | 1473-1150 1470-269X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b1b1b97af86d343fa4bdda5b68572fTest http://europepmc.org/articles/PMC3965567Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....84b1b1b97af86d343fa4bdda5b68572f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14731150 1470269X |
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