Erratum: Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner
| العنوان: | Erratum: Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner |
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| المؤلفون: | Jerome I. Rotter, Elizabeth Theusch, Kristen Stevens, Marisa W. Medina, Joshua D. Smith, Kyungpil Kim, Y-Di Chen, Deborah A. Nickerson |
| المصدر: | The Pharmacogenomics Journal The pharmacogenomics journal, vol 17, iss 3 |
| بيانات النشر: | Nature Publishing Group UK, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Simvastatin, Pharmacogenomic Variants, Cardiovascular, chemistry.chemical_compound, Gene expression, 2.1 Biological and endogenous factors, Pharmacology & Pharmacy, Lymphocytes, Aetiology, Regulation of gene expression, Intracellular Signaling Peptides and Proteins, Pharmacology and Pharmaceutical Sciences, Middle Aged, Heart Disease, Treatment Outcome, Molecular Medicine, Original Article, lipids (amino acids, peptides, and proteins), Female, Erratum, Clinical pharmacology, medicine.drug, Adult, medicine.medical_specialty, Statin, medicine.drug_class, Biology, Cell Line, 03 medical and health sciences, Medical research, Sex Factors, Clinical Research, Internal medicine, medicine, Genetics, Humans, Genetic variation, Triglycerides, Aged, Dyslipidemias, Pharmacology, Cholesterol, Membrane Proteins, Atherosclerosis, 030104 developmental biology, Endocrinology, chemistry, Gene Expression Regulation, Cell culture, Pharmacogenetics, sense organs, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Lipoprotein |
| الوصف: | Statins are widely prescribed to lower plasma low-density lipoprotein (LDL) cholesterol levels. They also modestly reduce plasma triglyceride (TG), an independent cardiovascular disease risk factor, in most people. The mechanism and inter-individual variability of TG statin response is poorly understood. We measured statin-induced gene expression changes in lymphoblastoid cell lines derived from 150 participants of a simvastatin clinical trial and identified 23 genes (false discovery rate, FDR=15%) with expression changes correlated with plasma TG response. The correlation of insulin-induced gene 1 (INSIG1) expression changes with TG response (rho=0.32, q=0.11) was driven by men (interaction P=0.0055). rs73161338 was associated with INSIG1 expression changes (P=5.4 × 10−5) and TG response in two statin clinical trials (P=0.0048), predominantly in men. A combined model including INSIG1 expression level and splicing changes accounted for 29.5% of plasma TG statin response variance in men (P=5.6 × 10−6). Our results suggest that INSIG1 variation may contribute to statin-induced changes in plasma TG in a sex-specific manner. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1473-1150 1470-269X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88291aa2d437cae4b6a6363d3372888eTest http://europepmc.org/articles/PMC7608431Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....88291aa2d437cae4b6a6363d3372888e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14731150 1470269X |
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