Solid pseudopapillary tumor of the pancreas: E-cadherin, β-catenin, CD99 new useful markers with characteristic expression (about two case reports)
| العنوان: | Solid pseudopapillary tumor of the pancreas: E-cadherin, β-catenin, CD99 new useful markers with characteristic expression (about two case reports) |
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| المؤلفون: | Nechi Salwa, Dhouib Rym, Doghri Raoudha, Charfi Lamia, Abbes Imen, Driss Maha, Mrad Karima |
| المصدر: | The Pan African Medical Journal Pan African Medical Journal; Vol. 40 No. 1 (2021) |
| بيانات النشر: | The African Field Epidemiology Network, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | E-cadherin, case report, CD99, β-catenin, Solid pseudo-papillary tumor of the pancreas |
| الوصف: | Solid pseudopapillary neoplasm of the pancreas is a rare tumor that has favorable prognosis. It poses frequently diagnostic challenges. We describe two cases of solid pseudopapillary tumor of the pancreas managed in our department between 2007 and 2011. Two females have mean age of 36.5 years. Clinical presentation include: abdominal pain, bloating and palpable abdominal mass. Tumor is localized in the head of the pancreas in one case and in the tail in the other case. The mean size of the mass was 6 cm (range: 5 to 7 cm). Surgical treatment was performed in two cases. Histological examination confirms the diagnosis of solid pseudopapillary tumor of the pancreas. Immunohistochemical analysis was concordant to the literature data especially concerning CD99 which positivity was in dot, loss of positivity of E-cadherin and nuclear staining of β-catenin. CD10 and α-1-antitrypsin were also positive. One patient was dead 3 days postoperative and neither cancer recurrence nor distant metastases were detected on the follow up of the other. However, solid pseudo-papillary tumor of the pancreas has a distinctive histological appearance; some cases are problematic requiring the use of immunohistochemistry to distinguish it from other pancreatic neoplasm which prognosis is different. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1937-8688 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6812b8ce050884ba0a0d343acee5d3b7Test http://europepmc.org/articles/PMC8627137Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....6812b8ce050884ba0a0d343acee5d3b7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19378688 |
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