Sputum or blood eosinophil association with clinical measures of COPD severity in the SPIROMICS cohort
| العنوان: | Sputum or blood eosinophil association with clinical measures of COPD severity in the SPIROMICS cohort |
|---|---|
| المؤلفون: | Hastie, AT, Martinez, FJ, Curtis, JL, Doerschuk, CM, Hansel, NN, Christenson, S, Putcha, N, Ortega, VE, Li, X, Barr, RG, Carretta, EE, Couper, DJ, Cooper, CB, Hoffman, EA, Kanner, RE, Kleerup, E, O’Neal, WK, Paine, R, Peters, SP, Alexis, NE, Woodruff, PG, Han, MK, Meyers, DA, Bleecker, ER |
| المصدر: | The Lancet. Respiratory medicine |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | respiratory system, Article, Asthma, respiratory tract diseases, hyperinflation, Eosinophils, Leukocyte Count, Pulmonary Disease, Chronic Obstructive, emphysema, COPD severity, air-trapping, Forced Expiratory Volume, Humans, airway eosinophilia |
| الوصف: | Background Eosinophils in blood and sputum in chronic obstructive pulmonary disease (COPD) have been associated with more frequent exacerbations, lower lung function, and corticosteroid responsiveness. We hypothesized increased eosinophils are associated with a severe COPD phenotype, including exacerbation frequency, and tested whether blood eosinophils reliably predict sputum eosinophils. Methods Comprehensive baseline data on SPIROMICS subjects, recruited for a range of COPD severity for smokers with ≥20 pack year history, included demographics, questionnaires, clinical assessments, quantitative computed tomography (QCT), blood and induced sputum. Findings Significantly, stratification by mean sputum eosinophils ≥1·25% (N=827) was associated with reduced FEV1 % predicted (differences: 10% pre-bronchodilator, 4·7% post-bronchodilator), QCT density measures for emphysema and air trapping, and exacerbations treated with corticosteroids (p=0·002). In contrast, stratification by mean blood eosinophils ≥200/µL (N=2499) showed that FEV1 % predicted was significant between low and high blood subgroups, but less than observed between sputum subgroups (blood eosinophil group differences: 4·2% pre-bronchodilator, 2·7% post-bronchodilator), slightly increased airway wall thickness (0·02 mm, p=0·032), greater symptoms (p=0·037), and wheezing (p=0·018), but no evidence of association with COPD exacerbations or other indices of severity. Blood eosinophils showed weak although significant association with sputum eosinophils (ROC AUC=0·64, p |
| اللغة: | English |
| تدمد: | 2213-2619 2213-2600 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::b44862342d1421a7b60aa90e73205d0aTest http://europepmc.org/articles/PMC5849066Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........b44862342d1421a7b60aa90e73205d0a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22132619 22132600 |
|---|