التفاصيل البيبلوغرافية
| العنوان: |
Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial |
| المؤلفون: |
Calfee, Carolyn S, Delucchi, Kevin L, Sinha, Pratik, Matthay, Michael A, Hackett, Jonathan, Shankar-Hari, Manu, McDowell, Cliona, Laffey, John G, O'Kane, Cecilia M, McAuley, Daniel F, Johnston, Andrew J, Paikray, Archana, Yates, Cat, Polgarova, Petra, Price, Esther, McInerney, Amy, Zamoscik, Katarzyna, Dempsey, Ged, Seasman, Colette, Gilfeather, Lynn, Hemmings, Noel, O'Kane, Sinead, Johnston, Paul, Pokorny, Lukas, Nutt, Chris, O'Neill, Orla, Prashast, Prashast, Smalley, Chris, Jacob, Reni, O'Rourke, James, Sultan, Syed Farjad, Schilling, Carole, Perkins, Gavin D, Melody, Teresa, Couper, Keith, Daniels, Ron, Gao, Fang, Hull, Julian, Gould, Timothy, Thomas, Matthew, Sweet, Katie, Breen, Dorothy, Neau, Emer, Peel, Willis J, Jardine, Catherine, Jefferson, Paul, Wright, Stephen E, Harris, Kayla, Thomas, Matthew, Hierons, Sarah, Laffey, John, McInerney, Veronica, Camporota, Luigi, Lei, Katie, Kaul, Sundeep, Chibvuri, Molly, Gratrix, Andrew, Bennett, Rachael, Martinson, Victoria, Sleight, Lisa, Smith, Neil, Hopkins, Philip A, Hadfield, Daniel, Casboult, Sarah, Wade-Smith, Fiona, Dawson, Julie, Mellis, Clare, Harris, Clair, Parsons, Georgina, Helyar, Sinead, Bodenham, Andrew R, Elliot, Stuart, Beardow, Zoe, Birch, Sian, Marsh, Brian, Martin, Teresa, Dhrampal, Akesh, Rosbergen, Melissa, Webb, Stephen, Bottrill, Fiona, Reschreiter, Henrik, Barcraft-Barnes, Helena, Camsooksai, Julie, Johnston, Andrew, Clarkson, Aisling, Bentley, Conor, Cooper, Lauren, Qui, Yongyan, Mitchell, Natalie, Carrera, Ronald, Whitehouse, Arlo, Danbury, Christopher M, Jacques, Nicola, Brown, Abby, Rogerson, David, Morris, Craig, Walsh, Timothy, Gillies, Mike, Price, Grant, Kefala, Kallirroi, Young, Neil, Hope, David, McCulloch, Corrienne, Antonelli, Jean, Ramsay, Pam, Everingham, Kirsty, Boardman, Louise, Dawson, Heidi, Pollock, Fiona, Thompson, Joanne, Welters, Ingeborg D, Poole, Lee, Hampshire, Peter, Hall, Alison, Williams, Karen, Walker, Anna, Youds, Laura, Hendry, Samantha, Waugh, Victoria, Patrick-Heselton, Julie, Shaw, David, Chaudry, Irfan, Baldwin, Jacqueline, Drage, Stephen, Ortiz-Ruiz de Gordoa, Laura, McAuley, Daniel, Bannon, Leona, Quinn, Vanessa, McNamee, Lia, White, Griania, Cecconi, Maurizio, Mellinghoff, Johannes, Ryan, Donal, Nichol, Alistair, Agarwal, Banwari, Meale, Paula, James, Sarah, Dhadwal, Kulwant, Martin, Daniel, Walecka, Agnieszka, Ward, Stephen, Trinder, John, Hagan, Samantha, Montgomery, Janice, Leonard, Catherine, Lemon, Elizabeth, Trinick, Tom, Buddhavarapu, Murthy, Ward, Geraldine, Bassford, Christopher, Davidson, Alan, McGuigan, Kate, Benchiheub, Anissa, Hickey, Naomi, Binning, Alexander, Henderson, Steven, Wood, J A, Burtenshaw, Andrew J, Kelly, Dawn, Martin, Terry, Thrush, Jessica, Wollaston, Julie, Graystone, Stephen, Nicol, Gavin, Sellors, Gareth |
| المصدر: |
The Lancet Respiratory Medicine; September 2018, Vol. 6 Issue: 9 p691-698, 8p |
| مستخلص: |
Precision medicine approaches that target patients on the basis of disease subtype have transformed treatment approaches to cancer, asthma, and other heterogeneous syndromes. Two distinct subphenotypes of acute respiratory distress syndrome (ARDS) have been identified in three US-based clinical trials, and these subphenotypes respond differently to positive end-expiratory pressure and fluid management. We aimed to investigate whether these subphenotypes exist in non-US patient populations and respond differently to pharmacotherapies. |
| قاعدة البيانات: |
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