التفاصيل البيبلوغرافية
| العنوان: |
Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial |
| المؤلفون: |
Bolaños-Meade, Javier, Cooke, Kenneth R, Gamper, Christopher J, Ali, Syed Abbas, Ambinder, Richard F, Borrello, Ivan M, Fuchs, Ephraim J, Gladstone, Douglas E, Gocke, Christian B, Huff, Carol Ann, Luznik, Leo, Swinnen, Lode J, Symons, Heather J, Terezakis, Stephanie A, Wagner-Johnston, Nina, Jones, Richard J, Brodsky, Robert A |
| المصدر: |
The Lancet Haematology; April 2019, Vol. 6 Issue: 4 pe183-e193, 11p |
| مستخلص: |
Although severe haemoglobinopathies can be cured with allogeneic blood or bone marrow transplantation, availability of matched donors and toxic effects can be problematic. We previously found that non-myeloablative haploidentical related bone marrow transplantation with post-transplantation cyclophosphamide expanded the donor pool while limiting graft-versus-host disease (GVHD). However, graft failure—albeit with full host haemopoietic recovery—occurred in 50% of patients. In this study, we investigated whether increasing total body irradiation from 200 cGy to 400 cGy would improve engraftment while maintaining the safety profile. |
| قاعدة البيانات: |
Supplemental Index |
