Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

التفاصيل البيبلوغرافية
العنوان: Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials
المؤلفون: Sawitzki, Birgit, Harden, Paul N, Reinke, Petra, Moreau, Aurélie, Hutchinson, James A, Game, David S, Tang, Qizhi, Guinan, Eva C, Battaglia, Manuela, Burlingham, William J, Roberts, Ian S D, Streitz, Mathias, Josien, Régis, Böger, Carsten A, Scottà, Cristiano, Markmann, James F, Hester, Joanna L, Juerchott, Karsten, Braudeau, Cecile, James, Ben, Contreras-Ruiz, Laura, van der Net, Jeroen B, Bergler, Tobias, Caldara, Rossana, Petchey, William, Edinger, Matthias, Dupas, Nathalie, Kapinsky, Michael, Mutzbauer, Ingrid, Otto, Natalie M, Öllinger, Robert, Hernandez-Fuentes, Maria P, Issa, Fadi, Ahrens, Norbert, Meyenberg, Christoph, Karitzky, Sandra, Kunzendorf, Ulrich, Knechtle, Stuart J, Grinyó, Josep, Morris, Peter J, Brent, Leslie, Bushell, Andrew, Turka, Laurence A, Bluestone, Jeffrey A, Lechler, Robert I, Schlitt, Hans J, Cuturi, Maria C, Schlickeiser, Stephan, Friend, Peter J, Miloud, Tewfik, Scheffold, Alexander, Secchi, Antonio, Crisalli, Kerry, Kang, Sang-Mo, Hilton, Rachel, Banas, Bernhard, Blancho, Gilles, Volk, Hans-Dieter, Lombardi, Giovanna, Wood, Kathryn J, Geissler, Edward K
المصدر: The Lancet; May 2020, Vol. 395 Issue: 10237 p1627-1639, 13p
مستخلص: Use of cell-based medicinal products (CBMPs) represents a state-of-the-art approach for reducing general immunosuppression in organ transplantation. We tested multiple regulatory CBMPs in kidney transplant trials to establish the safety of regulatory CBMPs when combined with reduced immunosuppressive treatment.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:01406736
1474547X
DOI:10.1016/S0140-6736(20)30167-7