دورية أكاديمية
The diagnostic significance of hepatitis C virus antibody levels for chronic hepatitis C virus infection
| العنوان: | The diagnostic significance of hepatitis C virus antibody levels for chronic hepatitis C virus infection |
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| المؤلفون: | Jin Gu Kang, Myoung Kuk Jang, Jung Hee Kim, Jang Han Jung, Ji Won Park, Sung Eun Kim, Sang Hoon Park, Myung Seok Lee, Ki Tae Suk, Dong Joon Kim, Hyoung Su Kim |
| المصدر: | The Korean Journal of Internal Medicine, Vol 38, Iss 3, Pp 362-371 (2023) |
| بيانات النشر: | The Korean Association of Internal Medicine, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | hepatitis c, hepatitis c antibody, prevalence, Medicine |
| الوصف: | Background/Aims Although anti-hepatitis C virus (HCV) assay is widely used to screen for HCV infection, it has a high false-positive (FP) rate in low-risk populations. We investigated the accuracy of anti-HCV signal-to-cutoff (S/CO) ratio to distinguish true-positive (TP) from FP HCV infection. Methods We retrospectively analyzed 77,571 patients with anti-HCV results. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic accuracy of anti-HCV S/CO ratio in anti-HCV positive patients. Results Overall, 1,126 patients tested anti-HCV positive; 34.7% of patients were FP based on HCV RNA and/or recombinant immunoblot assay (RIBA) results. The age and sex-adjusted anti-HCV prevalence was 1.22%. We identified significant differences in serum aspartate transaminase and alanine transaminase levels, anti-HCV S/CO ratio, and RIBA results between groups (viremia vs. non-viremia, TP vs. FP). Using ROC curves, the optimal cutoff values of anti-HCV S/CO ratio for HCV viremia and TP were 8 and 5, respectively. The area under the ROC curve, sensitivity, specificity, positive and negative predictive values were 0.970 (95% CI, 0.959–0.982, p < 0.001), 99.7%, 87.5%, 87.4%, and 99.7%, respectively, for predicting HCV viremia at an anti-HCV S/CO ratio of 8 and 0.987 (95% CI, 0.980–0.994, p < 0.001), 95.3%, 94.7%, 97.1%, and 91.4%, respectively, for TP HCV infection at an anti-HCV S/CO ratio of 5. No patients with HCV viremia had an anti-HCV S/CO ratio below 5. Conclusions The anti-HCV S/CO ratio is highly accurate for discriminating TP from FP HCV infection and should be considered when diagnosing HCV infections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1226-3303 2005-6648 |
| العلاقة: | http://www.kjim.org/upload/kjim-2022-350.pdfTest; https://doaj.org/toc/1226-3303Test; https://doaj.org/toc/2005-6648Test |
| DOI: | 10.3904/kjim.2022.350 |
| الوصول الحر: | https://doaj.org/article/42eaf79331a84b0099993400cc9e578bTest |
| رقم الانضمام: | edsdoj.42eaf79331a84b0099993400cc9e578b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12263303 20056648 |
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| DOI: | 10.3904/kjim.2022.350 |