Use of imaging during symptomatic follow-up after resection of pancreatic ductal adenocarcinoma
| العنوان: | Use of imaging during symptomatic follow-up after resection of pancreatic ductal adenocarcinoma |
|---|---|
| المؤلفون: | I. Quintus Molenaar, Hjalmar C. van Santvoort, Jeroen Hagendoorn, Vincent P. Groot, Inne H.M. Borel Rinkes, Lois A. Daamen |
| المصدر: | Journal of Surgical Research, 221, 152. Academic Press Inc. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Oncology, Diagnostic Imaging, Male, medicine.medical_specialty, Pancreatic ductal adenocarcinoma, Pancreatic neoplasms, Survival, medicine.medical_treatment, Follow-up studies, Disease, Resection, 03 medical and health sciences, Pancreatectomy, 0302 clinical medicine, Recurrence, Internal medicine, Post-hoc analysis, medicine, Medical imaging, Humans, Prospective cohort study, Aged, Netherlands, Proportional hazards model, business.industry, Middle Aged, Pancreatic Neoplasms, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Surgery, Female, Radiology, Neoplasm Recurrence, Local, business, Carcinoma, Pancreatic Ductal |
| الوصف: | Background Controversy exists whether follow-up after resection of pancreatic ductal adenocarcinoma (PDAC) should include standardized imaging for the detection of disease recurrence. The purpose of this study was to evaluate how often patients undergo imaging in a setting where routine imaging is not performed. Secondly, the pattern, timing, and treatment of recurrent PDAC were assessed. Materials and methods This was a post hoc analysis of a prospective database of all consecutive patients undergoing pancreatic resection of PDAC between January 2011 and January 2015. Data on imaging procedures during follow-up, recurrence location, and treatment for recurrence were extracted and analyzed. Associations between clinical characteristics and post-recurrence survival were assessed with the log-rank test and Cox univariable and multivariable proportional hazards models. Results A total of 85 patients were included. Seventy-four patients (87%) underwent imaging procedures during follow-up at least once, with a mean amount of 3.1 ± 1.9 imaging procedures during the entire follow-up period. Sixty-eight patients (80%) were diagnosed with recurrence, 58 (85%) of whom after the manifestation of clinical symptoms. Additional tumor-specific treatment was administered in 17 of 68 patients (25%) with recurrence. Patients with isolated local recurrence, treatment after recurrence, and a recurrence-free survival >10 mo had longer post-recurrence survival. Conclusions Even though a symptomatic follow-up strategy does not include routine imaging, the majority of patients with resected PDAC underwent additional imaging procedures during their follow-up period. Further prospective studies are needed to determine the actual clinical value, psychosocial implications, and cost-effectiveness of different forms of follow-up after resection of PDAC. |
| وصف الملف: | image/pdf |
| تدمد: | 1095-8673 0022-4804 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f8254aa994b5703e6c863c489c5e0cTest https://pubmed.ncbi.nlm.nih.gov/29229122Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e2f8254aa994b5703e6c863c489c5e0c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10958673 00224804 |
|---|