Chemotherapy and vitamin D supplement use are determinants of serum 25-hydroxyvitamin D levels during the first six months after colorectal cancer diagnosis
| العنوان: | Chemotherapy and vitamin D supplement use are determinants of serum 25-hydroxyvitamin D levels during the first six months after colorectal cancer diagnosis |
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| المؤلفون: | Dieuwertje E. Kok, Matty P. Weijenberg, Jody van den Ouweland, Bibi M.E. Hansson, Merel Snellen, Eline H. van Roekel, Fränzel J.B. van Duijnhoven, Evertine Wesselink, Renger F. Witkamp, Martijn J.L. Bours, Eric T.P. Keulen, Moniek van Zutphen, Renate M. Winkels, Johannes H. W. de Wilt, Ellen Kampman, Stéphanie O. Breukink, Michiel Aquarius |
| المساهمون: | Epidemiologie, RS: GROW - R1 - Prevention, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health |
| المصدر: | Journal of Steroid Biochemistry and Molecular Biology, 199 Journal of Steroid Biochemistry and Molecular Biology, 199:105577. Elsevier Science Journal of Steroid Biochemistry and Molecular Biology 199 (2020) |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Nutrition and Disease, Colorectal cancer, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, serum 25(OH)D-3, Disease, Biochemistry, Gastroenterology, Body Mass Index, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Endocrinology, Quality of life, QUALITY-OF-LIFE, Voeding en Ziekte, Vitamin D, Stage (cooking), POPULATION, education.field_of_study, SUN, Middle Aged, Nutritional Biology, Changes over time, 030220 oncology & carcinogenesis, SURVIVAL, Molecular Medicine, Female, HEALTH, Colorectal Neoplasms, Lifestyle and clinical determinants, medicine.medical_specialty, Patients, Population, STYLE, D DEFICIENCY, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Internal medicine, medicine, Vitamin D and neurology, Humans, education, Molecular Biology, Aged, Neoplasm Staging, VLAG, Chemotherapy, business.industry, MORTALITY, serum 25(OH)D, Cell Biology, Vitamin D Deficiency, medicine.disease, Radiation therapy, 030104 developmental biology, Dietary Supplements, Linear Models, Calcium, business |
| الوصف: | Vitamin D metabolites, including 25-hydroxyvitamin D3 (25(OH)D3), may inhibit colorectal cancer (CRC) progression. Here we investigated cross-sectional and longitudinal associations of demographic, lifestyle and clinical characteristics with 25(OH)D3 serum concentrations in CRC patients at diagnosis and six months later. In 1201 newly-diagnosed stage I-III CRC patients, 25(OH)D3 levels were analysed twice. Multivariable linear regression was used to assess demographic, lifestyle and clinical determinants of 25(OH)D3 levels at diagnosis and six months later. Linear mixed models were used to assess characteristics associated with changes in 25(OH)D3 levels over time. Results of our study showed that vitamin D intake from diet or supplements, use of calcium supplements, BMI and disease stage were associated with 25(OH)D3 levels at both time points. Six months after diagnosis, gender and having received chemo- and/or radiotherapy were also associated with 25(OH)D3 levels. A stronger decrease in 25(OH)D3 levels was observed in patients who underwent chemotherapy, compared to surgery only (β-6.9 nmol/L 95 %CI -9.8; -4.0). Levels of 25(OH)D3 levels increased in patients using vitamin D supplements compared to non-users (β 4.0 nmol/L 95 %CI 1.2; 6.8). In conclusion, vitamin D supplement use and treatment appear to be important determinants of 25(OH)D3 levels during the first six months after CRC diagnosis, although the difference in 25(OH)D3 levels was minor. ClinicalTrials.gov Identifier: NCT03191110. |
| وصف الملف: | application/octet-stream; application/pdf |
| تدمد: | 0960-0760 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c280208582a2fee8f55d832d6948705bTest https://doi.org/10.1016/j.jsbmb.2020.105577Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c280208582a2fee8f55d832d6948705b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09600760 |
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