FIBROBLAST GROWTH FACTOR 1 AND FIBROBLAST GROWTH FACTOR 2 IMMUNOREACTIVITY IN GASTROINTESTINAL TUMOURS
| العنوان: | FIBROBLAST GROWTH FACTOR 1 AND FIBROBLAST GROWTH FACTOR 2 IMMUNOREACTIVITY IN GASTROINTESTINAL TUMOURS |
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| المؤلفون: | Massimo Pignatelli, Iman El-Hariry, Nicholas R. Lemoine |
| المصدر: | The Journal of Pathology. 181:39-45 |
| بيانات النشر: | Wiley, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Adenoma, Adult, Male, Pathology, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Colorectal adenoma, Pathology and Forensic Medicine, Immunoenzyme Techniques, Paracrine signalling, Stomach Neoplasms, medicine, Humans, Autocrine signalling, Aged, Gastrointestinal Neoplasms, Aged, 80 and over, business.industry, Growth factor, Stomach, Middle Aged, medicine.disease, medicine.anatomical_structure, Fibroblast Growth Factor 1, Adenocarcinoma, Female, Fibroblast Growth Factor 2, Colorectal Neoplasms, business |
| الوصف: | Acidic and basic fibroblast growth factors (FGF-1 and FGF-2) are mitogenic polypeptides that may play a role in autocrine and paracrine growth control of malignant tumours. We have examined the expression of FGF-1 and FGF-2 in a series of 41 colorectal tumours (24 adenomas, 17 adenocarcinomas) and 50 gastric adenocarcinomas (23 intestinal, 27 diffuse), using immunohistochemistry. Whereas the FGF-1 distribution was cytoplasmic, FGF-2 was restricted to the nuclei of the epithelial cells. FGF-1 immunoreactivity was detected in all samples (100 per cent), whereas FGF-2 immunoreactivity was seen in 17 adenomas (71 per cent), 13 colorectal carcinomas (76 per cent), and 29 gastric carcinomas (58 per cent). Compared with the normal mucosa, FGF-1 was overexpressed in 42 per cent of colorectal adenomas, 76 per cent of colorectal cancers, and 54 per cent of gastric cancers. Conversely, FGF-2 expression was reduced in 16 (66 per cent), 8 (47 per cent), and 40 (80 per cent) adenomas and colorectal and gastric samples, respectively. We found a significant correlation only between reduced FGF-2 and gastric tumour grade. These data indicate that FGF-1 overexpression occurs in a large proportion of human colorectal and gastric cancers. This may play a role in the progression of these tumours. The topographic variation in FGF-2 expression between normal (nuclear) and tumour (cytoplasmic) cells implies a corresponding functional change that may in turn facilitate tumour growth. |
| تدمد: | 1096-9896 0022-3417 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fcd8d3f416358beda8e7d7418fc65aTest https://doi.org/10.1002Test/(sici)1096-9896(199701)181:1<39::aid-path711>3.0.co;2-c |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d9fcd8d3f416358beda8e7d7418fc65a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969896 00223417 |
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