GnRH Antagonist Cetrorelix Administration Before hCG for Protection of Ovarian Hyperstimulation Syndrome
| العنوان: | GnRH Antagonist Cetrorelix Administration Before hCG for Protection of Ovarian Hyperstimulation Syndrome |
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| المؤلفون: | Hassan N. Sallam, Banan A. Aboelazm, Sherif A. Hebisha |
| المصدر: | The Journal of Obstetrics and Gynecology of India. 67:270-274 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Gynecology, Infertility, Agonist, medicine.medical_specialty, 030219 obstetrics & reproductive medicine, business.industry, medicine.drug_class, GnRH Antagonist, Antagonist, Obstetrics and Gynecology, Ovarian hyperstimulation syndrome, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Cetrorelix, medicine, Original Article, 030212 general & internal medicine, Live birth, business, Prospective cohort study, reproductive and urinary physiology, hormones, hormone substitutes, and hormone antagonists, medicine.drug |
| الوصف: | Studying the effect of GnRH antagonist administration on the day of hCG to cases of IVF/ICSI with estradiol level above 5000 ng/dl for protection of ovarian hyperstimulation syndrome. Prospective study. Sixty patients undergoing controlled hyperstimulation COH, for IVF/ICSI using long agonist and E2 level on the day of hCG, are above 5000 ng/dl, 52 patients received single dose of cetrorelix 0.25 mg on the day of hCG, and 8 patients received two doses of 0.25 mg/day cetrorelix started one day before the day of hCG. There was no significant difference regarding patients BMI, number of stimulation days, recombinant FSH dose, and number of retrieved oocytes. Clinical pregnancy rate was 76.6% (46/60), in patients received single dose of antagonist PR were significantly higher 80.7% (42/52) versus 50% (4/8) in patients received two doses p = 0.047. Live birth rate was 50% (30/60), abortion rate was 20% (12/60), and preterm delivery was 20% (12/60). Mean E2 was 6853.2 ng/dl. Six patients developed moderate ovarian hyperstimulation OHSS (6/60) 10% and no cases of severe OHSS. GnRH antagonist administration on the day of hCG in cases undergoing IVF/ICSI with long agonist protocol is effective in protection of OHSS and does not affect the clinical pregnancy rate nor live birth rate. |
| تدمد: | 0975-6434 0971-9202 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b7331f5037df6eece6b6664c77bc81Test https://doi.org/10.1007/s13224-016-0952-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c1b7331f5037df6eece6b6664c77bc81 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09756434 09719202 |
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