Metabolic Profiling Reveals Differences in Plasma Concentrations of Arabinose and Xylose after Consumption of Fiber-Rich Pasta and Wheat Bread with Differential Rates of Systemic Appearance of Exogenous Glucose in Healthy Men
| العنوان: | Metabolic Profiling Reveals Differences in Plasma Concentrations of Arabinose and Xylose after Consumption of Fiber-Rich Pasta and Wheat Bread with Differential Rates of Systemic Appearance of Exogenous Glucose in Healthy Men |
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| المؤلفون: | Roel J. Vonk, Leo van Stee, Marion G. Priebe, Ivana Bobeldijk, A.J. Pantophlet, Johanna H. M. Stroeve, Coby Eelderink, Suzan Wopereis, Sabina Bijlsma |
| المصدر: | Journal of Nutrition, 2, 147, 152-160 The Journal of Nutrition, 147(2), 152-160. Oxford University Press |
| بيانات النشر: | Oxford University Press, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Arabinose, Dietary Fiber, Male, ALPHA-AMYLASE, Metabolite, ACTIVE CELIAC-DISEASE, Medicine (miscellaneous), Xylose, Wheat bran, chemistry.chemical_compound, Starch digestion, Arabinoxylan, Food science, Triticum, GLYCEMIC RESPONSE, Meal, Nutrition and Dietetics, Cross-Over Studies, food and beverages, Bread, Life Triskelion BV, ELSS - Earth, Life and Social Sciences TNO Bedrijven, Postprandial Period, MICROBIOTA, Postprandial, CARDIOVASCULAR-DISEASE, OBESITY, Healthy men, Healthy Living, wheat bran, ARABINOXYLANS, Postprandial metabolomics, Pasta, bread, Biology, 03 medical and health sciences, Young Adult, Humans, Food and Nutrition, postprandial metabolomics, Nutrition, pasta, Bran, healthy men, HUMAN ILEAL, ADULTS, Bioavailability, arabinoxylan, 030104 developmental biology, Glucose, chemistry, starch digestion, MSB - Microbiology and Systems Biology RAPID - Risk Analysis for Products in Development MHR - Metabolic Health Research ARF - Analytical Research (Food), TOLERANCE TEST, Food Analysis |
| الوصف: | Background: The consumption of products rich in cereal fiber and with a low glycemic index is implicated in a lower risk of metabolic diseases. Previously, we showed that the consumption of fiber-rich pasta compared with bread resulted in a lower rate of appearance of exogenous glucose and a lower glucose clearance rate quantified with a dual-isotope technique, which was in accordance with a lower insulin and glucose-dependent insulinotropic polypeptide response.Objective: To gain more insight into the acute metabolic consequences of the consumption of products resulting in differential glucose kinetics, postprandial metabolic profiles were determined.Methods: In a crossover study, 9 healthy men (mean +/- SEM age: 21 +/- 0.5 y; mean SEM body mass index (kg/m(2)): 22 +/- 0.5] consumed wheat bread (132 g) and fresh pasta (119 g uncooked) enriched with wheat bran (10%) meals. A total of 134 different metabolites in postprandial plasma samples (at -5, 30, 60, 90, 120, and 180 min) were quantified by using a gas chromatography mass spectrometry based metabolomics approach (secondary outcomes). Two-factor ANOVA and advanced multivariate statistical analysis (partial least squares) were applied to detect differences between both food products.Results: Forty-two different postprandial metabolite profiles were identified, primarily representing pathways related to protein and energy metabolism, which were on average 8% and 7% lower after the men consumed pasta rather than bread, whereas concentrations of arabinose and xylose were 58% and 53% higher, respectively. Arabinose and xylose are derived from arabinoxylans, which are important components of wheat bran. The higher bioavailability of arabinose and xylose after pasta intake coincided with a lower rate of appearance of glucose and amino acids. We speculate that this higher bioavailability is due to higher degradation of arabinoxylans by small intestinal microbiota, facilitated by the higher viscosity of arabinoxylans after pasta intake than after bread intake.Conclusion: This study suggests that wheat bran, depending on the method of processing, can increase the viscosity of the meal bolus in the small intestine and interfere with macronutrient absorption in healthy men, thereby influencing postprandial glucose and insulin responses. This trial was registered at www.controlled-trials.com as ISRCTN42106325. |
| اللغة: | English |
| تدمد: | 1541-6100 0022-3166 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead548218e76e776a417db79f8b519bfTest https://doi.org/10.3945/jn.116.237404Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ead548218e76e776a417db79f8b519bf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15416100 00223166 |
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