التفاصيل البيبلوغرافية
| العنوان: |
Vγ9Vδ2 T-cells Are Potent Inhibitors of SARS-CoV-2 Replication and Represent Effector Phenotypes in Patients With COVID-19 |
| المؤلفون: |
Gay, Laetitia, Rouviere, Marie-Sarah, Mezouar, Soraya, Richaud, Manon, Gorvel, Laurent, Foucher, Etienne, La Scola, Bernard, Menard, Amélie, Allardet-Servent, Jérôme, Halfon, Philippe, Frohna, Paul, Cano, Carla, Mege, Jean-Louis, Olive, Daniel |
| المساهمون: |
Agence Nationale de la Recherche, Canceropôle Provence-Alpes-Côte d’Azur |
| المصدر: |
The Journal of Infectious Diseases ; ISSN 0022-1899 1537-6613 |
| بيانات النشر: |
Oxford University Press (OUP) |
| سنة النشر: |
2024 |
| الوصف: |
Vγ9Vδ2 T cells play a key role in the innate immune response to viral infections through butyrophilin 3A (BTN3A). Here, we report blood Vγ9Vδ2 T cells decreased in clinically mild COVID-19 compared to healthy volunteers, and this was maintained up to 28 days and in the recovery period. Terminally differentiated Vγ9Vδ2 T cells tended to be enriched on the day of diagnosis, 28 days after, and during the recovery period. These cells showed cytotoxic and inflammatory activities following anti-BTN3A activation. BTN3A upregulation and Vγ9Vδ2 T-cell infiltration were observed in a lung biopsy from a fatal SARS-CoV-2 infection. In vitro, SARS-CoV-2 infection increased BTN3A expression in macrophages and lung cells that enhanced the anti–SARS-CoV-2 Vγ9Vδ2 T-cell cytotoxicity and interferon-γ and tumor necrosis factor-α. Increasing concentrations of anti-BTN3A lead to viral replication inhibition. Altogether, we report Vγ9Vδ2 T cells are important in the immune response against SARS-CoV-2 infection and activation by anti-BTN3A antibody may enhance their response. Clinical Trials Registration. NCT04816760. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1093/infdis/jiae169 |
| DOI: |
10.1093/infdis/jiae169/57341002/jiae169.pdf |
| الإتاحة: |
https://doi.org/10.1093/infdis/jiae169Test |
| حقوق: |
https://academic.oup.com/pages/standard-publication-reuse-rightsTest |
| رقم الانضمام: |
edsbas.2A50D69A |
| قاعدة البيانات: |
BASE |
