A Prospective Study of Sexual Transmission of Human T Lymphotropic Virus (HTLV)–I and HTLV‐II
| العنوان: | A Prospective Study of Sexual Transmission of Human T Lymphotropic Virus (HTLV)–I and HTLV‐II |
|---|---|
| المؤلفون: | James W. Smith, Bruce Newman, S Hutching, Catharie C. Nass, Diana F. Roucoux, Daniel M. Chafets, Donna Smith, Htlv Outcomes Study (Host) Investigators, Tzong-Hae Lee, Baoguang Wang |
| المصدر: | The Journal of Infectious Diseases. 191:1490-1497 |
| بيانات النشر: | Oxford University Press (OUP), 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Sexually transmitted disease, Sexual transmission, viruses, Sexually Transmitted Diseases, Human T-lymphotropic virus, Virus, Cohort Studies, Risk Factors, immune system diseases, Humans, Immunology and Allergy, Aged, biology, Incidence, Incidence (epidemiology), Middle Aged, biology.organism_classification, HTLV-I Infections, Virology, United States, Deltaretrovirus, Cross-Sectional Studies, Infectious Diseases, Socioeconomic Factors, Human T-lymphotropic virus 1, HTLV-II Infections, Immunology, Human T-lymphotropic virus 2, Female |
| الوصف: | Author(s): Roucoux, Diana F; Wang, Baoguang; Smith, Donna; Nass, Catharie C; Smith, James; Hutching, Sheila T; Newman, Bruce; Lee, Tzong-Hae; Chafets, Daniel M; Murphy, Edward L; HTLV Outcomes Study Investigators | Abstract: BackgroundCross-sectional studies support sexual transmission of human T lymphotropic virus (HTLV)-I/II; however, prospective incidence data, particularly for HTLV-II, are limited.MethodsA cohort of 85 HTLV-positive (30 with HTLV-I and 55 with HTLV-II) blood donors and their stable (gor=6 months) heterosexual sex partners were followed biannually over the course of a 10-year period.ResultsFour of 85 initially seronegative sex partners of HTLV-I and -II carriers seroconverted, for an incidence rate (IR) of 0.6 transmissions/100 person-years (py) (95% confidence interval [CI], 0.2-1.6). This includes 2 HTLV-I transmissions/219 py (IR, 0.9 transmissions/100 py [95% CI, 0.1-3.3]) and 2 HTLV-II transmissions/411 py (IR, 0.5 transmissions/100 py [95% CI, 0.06-1.8]), with no significant difference by HTLV type. There were 2 male-to-female (IR, 1.2 transmissions/100 py [95% CI, 0.1-4.3]) and 2 female-to-male (IR, 0.4 transmissions/100 py [95% CI, 0.05-1.6) transmissions. HTLV-I or -II proviral load was 2 log10 lower in newly infected partners than in index positive partners who transmitted HTLV (P=.007).ConclusionsThe incidence of sexual transmission of HTLV-II may be similar to that of HTLV-I, and female-to-male transmission may play a more important role than previously thought. HTLV-I and -II proviral load may be lower in sexually acquired infection, because of a small infectious dose. |
| تدمد: | 1537-6613 0022-1899 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afeee5bebce7ae701ebd188f68c6cb5Test https://doi.org/10.1086/429410Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7afeee5bebce7ae701ebd188f68c6cb5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
|---|