Serologic Correlates of Immunity in a Tetravalent Reassortant Rotavirus Vaccine Trial
| العنوان: | Serologic Correlates of Immunity in a Tetravalent Reassortant Rotavirus Vaccine Trial |
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| المؤلفون: | Michael E. Mack, Richard L. Ward, Edward T. Zito, Ruth Rappaport, Douglas R. Knowlton, Bruce Davidson |
| المصدر: | The Journal of Infectious Diseases. 176:570-577 |
| بيانات النشر: | Oxford University Press (OUP), 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Serotype, biology, viruses, Antibody titer, virus diseases, Reoviridae, biology.organism_classification, medicine.disease_cause, Rotavirus vaccine, Virology, Vaccination, Titer, Infectious Diseases, Rotavirus, Immunology, biology.protein, medicine, Immunology and Allergy, Neutralizing antibody |
| الوصف: | The correlation of antibody responses (serum rotavirus IgA and neutralizing antibody to serotype G1-G4 human rotaviruses and rhesus rotavirus [RRV]) in a reassortant rotavirus vaccine trial with protection against rotavirus infection or disease was investigated. Most subjects administered 4 x 10(5) pfu of either the serotype G1 monovalent or serotype G1-G4 tetravalent vaccine seroconverted for at least one of the six antibodies (85% and 91%, respectively). However, fewer than one-third seroconverted to any prototype G1-G4 human rotavirus. Analyses of covariance indicated that higher prevaccination neutralizing antibody titers negatively affected postvaccination titers. Significant relationships were found between several postvaccination rotavirus antibody titers and protection, and serotype-specific correlates of protection were identified between anti-Wa titers and G1 illnesses (P = .03) and between anti-RRV titers and G3 illnesses (P < .001). Overall, however, serotype-specific immunity was no more significant than heterotypic immunity, and no specific titer of any antibody analyzed was a reliable indicator of protection. |
| تدمد: | 1537-6613 0022-1899 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::46e226c439a71c57f4b38d8f7e16f3daTest https://doi.org/10.1086/514076Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........46e226c439a71c57f4b38d8f7e16f3da |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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