Increasing Frequency and Transmission of HIV-1 Non-B Subtypes Among Men Who Have Sex With Men in the Swiss HIV Cohort Study
| العنوان: | Increasing Frequency and Transmission of HIV-1 Non-B Subtypes Among Men Who Have Sex With Men in the Swiss HIV Cohort Study |
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| المؤلفون: | Duran Ramirez, Jessy J, Ballouz, Tala, Nguyen, Huyen, Kusejko, Katharina, Chaudron, Sandra E, Huber, Michael, Hirsch, Hans H, Perreau, Matthieu, Ramette, Alban, Yerly, Sabine, Cavassini, Matthias, Stöckle, Marcel, Furrer, Hansjakob, Vernazza, Pietro, Bernasconi, Enos, Günthard, Huldrych F, Kouyos, Roger D, Aebi-Popp, K, Anagnostopoulos, A, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Calmy, A, Cavassini, M, Ciuffi, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, A Fux, C, Günthard, H F, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Huber, M, Kahlert, C R, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R D, Kovari, H, Kusejko, K, Ledergerber, B, Martinetti, G, Martinez de Tejada, B, Marzolini, C, Metzner, K J, Müller, N, Nicca, D, Paioni, P, Pantaleo, G, Perreau, M, Rauch, A, Rudin, C, Schmid, P, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Wandeler, G, Weber, R, Yerly, S |
| المساهمون: | University of Zurich |
| المصدر: | Duran Ramirez, Jessy J; Ballouz, Tala; Nguyen, Huyen; Kusejko, Katharina; Chaudron, Sandra E; Huber, Michael; Hirsch, Hans H; Perreau, Matthieu; Ramette, Alban; Yerly, Sabine; Cavassini, Matthias; Stöckle, Marcel; Furrer, Hansjakob; Vernazza, Pietro; Bernasconi, Enos; Günthard, Huldrych F; Kouyos, Roger D (2022). Increasing Frequency and Transmission of HIV-1 Non-B Subtypes among Men Who Have Sex with Men in the Swiss HIV Cohort Study. The journal of infectious diseases, 225(2), pp. 306-316. Oxford University Press 10.1093/infdis/jiab360 <http://dx.doi.org/10.1093/infdis/jiab360Test> The Journal of Infectious Diseases (2021) |
| مصطلحات موضوعية: | Adult, Male, 10028 Institute of Medical Virology, medicine.medical_specialty, Maximum likelihood, Human immunodeficiency virus (HIV), HIV Infections, 610 Medicine & health, Newly diagnosed, medicine.disease_cause, Men who have sex with men, Cohort Studies, 10234 Clinic for Infectious Diseases, 03 medical and health sciences, 0302 clinical medicine, HIV Seropositivity, medicine, Disease Transmission, Infectious, Immunology and Allergy, Humans, 030212 general & internal medicine, MSM, Prospective Studies, Homosexuality, Male, Phylogeny, 030304 developmental biology, ddc:616, 0303 health sciences, Molecular Epidemiology, Molecular epidemiology, Transmission (medicine), business.industry, Public health, virus diseases, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 3. Good health, Non-B subtypes, Infectious Diseases, HIV-1, 570 Life sciences, biology, business, Transmission cluster, 610 Medizin und Gesundheit, Switzerland, Demography, Cohort study, 570 Biowissenschaften, Biologie |
| الوصف: | Background In Switzerland, HIV-1 transmission among men who have sex with men (MSM) has been dominated by subtype B, whilst non-B subtypes are commonly attributed to infections acquired abroad among heterosexuals. Here, we evaluated the temporal trends of non-B subtypes and the characteristics of molecular transmission clusters (MTCs) among MSM. Methods Sociodemographic and clinical data and partial pol sequences were obtained from participants enrolled in the Swiss HIV Cohort Study. For non-B subtypes, maximum likelihood trees were constructed, from which Swiss MTCs were identified and analyzed by transmission group. Results Non-B subtypes were identified in 8.1% (416/5116) of MSM participants. CRF01_AE was the most prevalent strain (3.5%), followed by subtype A (1.2%), F (1.1%), CRF02_AG (1.1%), C (0.9%), and G (0.3%). Between 1990 and 2019, an increase in the proportion of newly diagnosed individuals (0/123 [0%] to 11/32 [34%]) with non-B subtypes in MSM was found. Across all non-B subtypes, the majority of MSM MTCs were European. Larger MTCs were observed for MSM than heterosexuals. Conclusions We found a substantial increase in HIV-1 non-B subtypes among MSM in Switzerland and the occurrence of large MTCs, highlighting the importance of molecular surveillance in guiding public health strategies targeting the HIV-1 epidemic. |
| وصف الملف: | jiab360.pdf - application/pdf; application/pdf |
| اللغة: | English |
| تدمد: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiab360 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8fabfbd21ee6086409cff2f1c97dc1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cb8fabfbd21ee6086409cff2f1c97dc1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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| DOI: | 10.1093/infdis/jiab360 |