Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease
| العنوان: | Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease |
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| المؤلفون: | Margaret James, Tiina Eriksson, Richard M. Haupt, Matti Lehtinen, Gonzalo L. Pérez, Jaime Enrique Ruiz, Ángela María Ruiz, Heather L. Sings, Andrés Velásquez Gavilanes |
| المصدر: | Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Sexual behavior, Time Factors, Oral contraceptive agent, Uterine Cervical Neoplasms, Sexual intercourse, Menstruation, Human papillomavirus type 18, Human papillomavirus type 6, Cancer risk, Clinical trials, Randomized controlled trial (topic), Human papillomavirus type 58, Human papillomavirus type 16, Uterine cervix carcinoma in situ, Human papillomavirus type 59, Immunology and Allergy, Human papillomavirus type 56, Young adult, Human papillomavirus type 11, Human papillomavirus type 52, Finland, Human papillomavirus type 51, Priority journal, Risk assessment, Coitus, Papanicolaou test, Polymerase chain reaction, Colombian, Infectious Diseases, medicine.anatomical_structure, Colposcopy, Virus dna, Menarche, Female, Human, Adult, medicine.medical_specialty, Uterine cervical neoplasms, Uterine cervix biopsy, Adolescent, Sexual Behavior, phase iii as topic, Major clinical study, Uterine cervix cytology, Adenocarcinoma, Colombia, Risk Assessment, Article, Papillomavirus infections, Human papillomavirus type 39, Wart virus, Young Adult, Condom, Human papillomavirus type 35, medicine, Humans, Human papillomavirus type 31, Post hoc analysis, Risk factor, Human papillomavirus type 33, Phase 3 clinical trial (topic), Cervix, Placebo, Gynecology, Cervical intraepithelial neoplasia, business.industry, Ethnic group, Time factors, Confidence interval, Finnish, Papillomavirus Infections, Odds ratio, Uterine Cervical Dysplasia, Clinical Trials, Phase III as Topic, Human papillomavirus type 45, business, Wart virus vaccine |
| الوصف: | Background We assessed if risk of developing cervical intraepithelial neoplasia grade 2/3 (CIN2/3) or adenocarcinoma in situ (AIS) is associated with a short interval between menarche and first sexual intercourse (FSI).Methods A total of 1009 Colombian and 1012 Finnish females, aged 16-23, who were enrolled in the phase 3 trials of a quadrivalent human papillomavirus (HPV) 6/11/16/18 vaccine had nonmissing data for age of menarche and FSI. The impact of menarche interval on the odds of developing CIN2-3/AIS was evaluated in placebo recipients who were DNA negative to HPV 6/11/16/18/31/33/35/39/45/51/52/56/58/59 and seronegative to HPV 6/11/16/18 at day 1, and had a normal Pap result at day 1 and month 7, thus approximating sexually naive adolescents (n = 504).Results The mean age of menarche and FSI was 12.4 and 16.0 years, respectively. Among the women approximating sexually naive adolescents, 18 developed CIN2-3/AIS. Compared with women who postponed FSI beyond 3 years of menarche, those with FSI within 3 years of menarche had a greater risk of cytologic abnormalities (odds ratio [OR], 1.65; 95% confidence interval [CI], 1.02-2.68; P =. 04) and CIN2-3/AIS (OR, 3.56; 95% CI, 1.02-12.47; P =. 05).Conclusions A short interval between menarche and FSI was a risk factor for cytologic abnormalities and high-grade cervical disease. These data emphasize the importance of primary prevention through education and vaccination.Clinical Trials Registration. NCT00092521 and NCT00092534. © 2012 The Author. |
| وصف الملف: | application/pdf |
| تدمد: | 1537-6613 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9f24a6bdc8d393ca6bf6113e6c247cTest https://pubmed.ncbi.nlm.nih.gov/23708400Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....da9f24a6bdc8d393ca6bf6113e6c247c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 |
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