Apoptotic Cells Activate NKT Cells through T Cell Ig-Like Mucin-Like–1 Resulting in Airway Hyperreactivity
| العنوان: | Apoptotic Cells Activate NKT Cells through T Cell Ig-Like Mucin-Like–1 Resulting in Airway Hyperreactivity |
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| المؤلفون: | Rosemarie H. DeKruyff, Sho Goya, José M. Casasnovas, Everett Meyer, Muriel Pichavant, Sarah E. Umetsu, Xia Bu, Jennifer Jones, Gordon J. Freeman, Hyun Hee Lee, Dale T. Umetsu, Yoichiro Iwakura, Hye Young Kim, Paul B. Savage, Gerardo G. Kaplan |
| المصدر: | The Journal of Immunology. 185:5225-5235 |
| بيانات النشر: | The American Association of Immunologists, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Programmed cell death, medicine.medical_treatment, T cell, Immunology, Apoptosis, Enzyme-Linked Immunosorbent Assay, Cell Separation, Phosphatidylserines, Biology, Lymphocyte Activation, Article, Flow cytometry, Mice, medicine, Animals, Immunology and Allergy, Hepatitis A Virus Cellular Receptor 1, Receptor, Mice, Knockout, Mice, Inbred BALB C, Microscopy, Confocal, medicine.diagnostic_test, Reverse Transcriptase Polymerase Chain Reaction, Pattern recognition receptor, Membrane Proteins, Flow Cytometry, Natural killer T cell, Asthma, Cell biology, Cytokine, medicine.anatomical_structure, Natural Killer T-Cells, Bronchial Hyperreactivity |
| الوصف: | T cell Ig-like mucin-like–1 (TIM-1) is an important asthma susceptibility gene, but the immunological mechanisms by which TIM-1 functions remain uncertain. TIM-1 is also a receptor for phosphatidylserine (PtdSer), an important marker of cells undergoing programmed cell death, or apoptosis. We now demonstrate that NKT cells constitutively express TIM-1 and become activated by apoptotic cells expressing PtdSer. TIM-1 recognition of PtdSer induced NKT cell activation, proliferation, and cytokine production. Moreover, the induction of apoptosis in airway epithelial cells activated pulmonary NKT cells and unexpectedly resulted in airway hyperreactivity, a cardinal feature of asthma, in an NKT cell-dependent and TIM-1–dependent fashion. These results suggest that TIM-1 serves as a pattern recognition receptor on NKT cells that senses PtdSer on apoptotic cells as a damage-associated molecular pattern. Furthermore, these results provide evidence for a novel innate pathway that results in airway hyperreactivity and may help to explain how TIM-1 and NKT cells regulate asthma. |
| تدمد: | 1550-6606 0022-1767 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7af853ebad5ce248cd98677ec7df5fTest https://doi.org/10.4049/jimmunol.1001116Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dd7af853ebad5ce248cd98677ec7df5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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