التفاصيل البيبلوغرافية
| العنوان: |
Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma |
| المؤلفون: |
Angelo Maffei, Marianna Storto, GianLuca Colussi, Alessandra Aretini, Ornella Azzolino, Mara Brancaccio, Fiorella Altruda, Maria Teresa Gentile, Giuseppe Lembo, Carmine Vecchione, Enrico Patrucco, Guido Tarone, Emilio Hirsch, Lorenzo Silengo, Umberto Bettarini, Roberta Poulet, Mathias P. Wymann, Gennaro Marino, Laura Barberis |
| المساهمون: |
Vecchione, Carmine, Patrucco, Enrico, Marino, Gennaro, Barberis, Laura, Poulet, Roberta, Aretini, Alessandra, Maffei, Angelo, Gentile, Maria Teresa, Storto, Marianna, Azzolino, Ornella, Brancaccio, Mara, Colussi, Gian Luca, Bettarini, Umberto, Altruda, Fiorella, Silengo, Lorenzo, Tarone, Guido, Wymann, Mathias P., Hirsch, Emilio, Lembo, Giuseppe |
| المصدر: |
The Journal of Experimental Medicine |
| سنة النشر: |
2005 |
| مصطلحات موضوعية: |
Male, medicine.medical_specialty, Angiotensin receptor, Immunology, hypertension, angiotensin, signal transduction, genetically modified mice, Muscle, Smooth, Vascular, Article, Mesenteric Arterie, Mice, Phosphatidylinositol 3-Kinases, Internal medicine, Renin–angiotensin system, medicine, Immunology and Allergy, Animals, Vasoconstrictor Agents, Protein kinase B, Aorta, Cells, Cultured, Phosphoinositide-3 Kinase Inhibitors, Mice, Knockout, Angiotensin II receptor type 1, biology, Animal, Angiotensin II, Angiotensin-converting enzyme, Smooth muscle contraction, medicine.disease, Isoenzyme, Mesenteric Arteries, Isoenzymes, Endocrinology, Vasoconstriction, Pathophysiology of hypertension, Hypertension, biology.protein, Calcium, Phosphatidylinositol 3-Kinase, Vasoconstrictor Agent, Reactive Oxygen Specie, Reactive Oxygen Species |
| الوصف: |
Hypertension affects nearly 20% of the population in Western countries and strongly increases the risk for cardiovascular diseases. In the pathogenesis of hypertension, the vasoactive peptide of the renin-angiotensin system, angiotensin II and its G protein-coupled receptors (GPCRs), play a crucial role by eliciting reactive oxygen species (ROS) and mediating vessel contractility. Here we show that mice lacking the GPCR-activated phosphoinositide 3-kinase (PI3K)γ are protected from hypertension that is induced by administration of angiotensin II in vivo. PI3Kγ was found to play a role in angiotensin II-evoked smooth muscle contraction in two crucial, distinct signaling pathways. In response to angiotensin II, PI3Kγ was required for the activation of Rac and the subsequent triggering of ROS production. Conversely, PI3Kγ was necessary to activate protein kinase B/Akt, which, in turn, enhanced L-type Ca2+ channel-mediated extracellular Ca2+ entry. These data indicate that PI3Kγ is a key transducer of the intracellular signals that are evoked by angiotensin II and suggest that blocking PI3Kγ function might be exploited to improve therapeutic intervention on hypertension. © The Rockefeller University Press. |
| تدمد: |
0022-1007 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f636655d96798c238a41a8031d3498cdTest
https://pubmed.ncbi.nlm.nih.gov/15824082Test |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....f636655d96798c238a41a8031d3498cd |
| قاعدة البيانات: |
OpenAIRE |
