Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain
| العنوان: | Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain |
|---|---|
| المؤلفون: | Francesca Aloisi, Roberta Magliozzi, Alberto Faggioni, Barbara Serafini, Laura Andreoni, Paola Cinque, Richard Reynolds, Barbara Rosicarelli, Diego Franciotta, Pankaj Trivedi, Marco Salvetti |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | The Rockefeller University Press, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Pathology, medicine.medical_specialty, Epstein-Barr Virus Infections, Multiple Sclerosis, Adolescent, rheumatoid synovitis, Immunology, Central nervous system, myelin basic-protein, Biology, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Virus, Article, transformed b-cells, Immunopathology, medicine, Immunology and Allergy, Humans, Age of Onset, Interleukin-7 receptor, Epstein–Barr virus infection, B cell, interleukin-7 receptor, Multiple sclerosis, T-cells, Brain, Articles, medicine.disease, Survival Analysis, cerebrospinal-fluid, Axons, medicine.anatomical_structure, antibody-synthesis, plasmacytoid dendritic cells, systemic-lupus-erythematosus, clonal expansions, CD8 |
| الوصف: | Epstein-Barr virus (EBV), a ubiquitous B-lymphotropic herpesvirus, has been associated with multiple sclerosis (MS), an inflammatory disease of the central nervous system (CNS), but direct proof of its involvement in the disease is still missing. To test the idea that MS might result from perturbed EBV infection in the CNS, we investigated expression of EBV markers in postmortem brain tissue from MS cases with different clinical courses. Contrary to previous studies, we found evidence of EBV infection in a substantial proportion of brain-infiltrating B cells and plasma cells in nearly 100% of the MS cases examined (21 of 22), but not in other inflammatory neurological diseases. Ectopic B cell follicles forming in the cerebral meninges of some cases with secondary progressive MS were identified as major sites of EBV persistence. Expression of viral latent proteins was regularly observed in MS brains, whereas viral reactivation appeared restricted to ectopic B cell follicles and acute lesions. Activation of CD8+ T cells with signs of cytotoxicity toward plasma cells was also noted at sites of major accumulations of EBV-infected cells. Whether homing of EBV-infected B cells to the CNS is a primary event in MS development or the consequence of a still unknown disease-related process, we interpret these findings as evidence that EBV persistence and reactivation in the CNS play an important role in MS immunopathology. |
| اللغة: | English |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d283e41af50569572d02aa43a21b95d7Test http://europepmc.org/articles/PMC2118531Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d283e41af50569572d02aa43a21b95d7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
|---|