Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice
| العنوان: | Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice |
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| المؤلفون: | Shohreh Issazadeh-Navikas, Saleh M. Ibrahim, Anna Teige, Yawei Liu, Emma Mondoc, Rikard Holmdahl |
| المصدر: | Journal of Clinical Investigation; Vol 121 Journal of Clinical Investigation; 121(1), pp 249-264 (2011) |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Lymphocyte Activation, Mice, 0302 clinical medicine, Hypersensitivity, Delayed, Mice, Knockout, 0303 health sciences, Antigen Presentation, biology, Vaccination, Peripheral tolerance, hemic and immune systems, General Medicine, Natural killer T cell, 3. Good health, medicine.anatomical_structure, CD1D, CD4 Antigens, Research Article, Encephalomyelitis, Autoimmune, Experimental, Fas Ligand Protein, T cell, CD8 Antigens, Antigen presentation, Genes, MHC Class II, CD1, chemical and pharmacologic phenomena, 03 medical and health sciences, Th2 Cells, MHC class I, medicine, Respiratory Hypersensitivity, Animals, fas Receptor, ATP Binding Cassette Transporter, Subfamily B, Member 2, Collagen Type II, 030304 developmental biology, DNA Primers, Inflammation, MHC class II, Base Sequence, Immunodominant Epitopes, Neurosciences, Immunology in the medical area, Th1 Cells, Arthritis, Experimental, Peptide Fragments, Mice, Inbred C57BL, Genes, T-Cell Receptor, Immunology, biology.protein, Natural Killer T-Cells, ATP-Binding Cassette Transporters, Antigens, CD1d, 030215 immunology |
| الوصف: | NKT cells in the mouse recognize antigen in the context of the MHC class I-like molecule CD1d and play an important role in peripheral tolerance and protection against autoimmune and other diseases. NKT cells are usually activated by CD1d-presented lipid antigens. However, peptide recognition in the context of CD1 has also been documented, although no self-peptide ligands have been reported to date. Here, we have identified an endogenous peptide that is presented by CD1d to activate mouse NKT cells. This peptide, the immunodominant epitope from mouse collagen type II (mCII707-721), was not associated with either MHC class I or II. Activation of CD1d-restricted mCII707-721-specific NKT cells was induced via TCR signaling and classical costimulation. In addition, mCII707-721-specific NKT cells induced T cell death through Fas/FasL, in an IL-17A-independent fashion. Moreover, mCII707-721-specific NKT cells suppressed a range of in vivo inflammatory conditions, including delayed-type hypersensitivity, antigen-induced airway inflammation, collagen-induced arthritis, and EAE, which were all ameliorated by mCII707-721 vaccination. The findings presented here offer new insight into the intrinsic roles of NKT cells in health and disease. Given the results, endogenous collagen peptide activators of NKT cells may offer promise as novel therapeutics in tissue-specific autoimmune and inflammatory diseases. |
| وصف الملف: | application/pdf |
| تدمد: | 1558-8238 0021-9738 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0218d9df8122e49cbb0ea0bfdbd814fTest https://pubmed.ncbi.nlm.nih.gov/21157037Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d0218d9df8122e49cbb0ea0bfdbd814f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15588238 00219738 |
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